Influence of Injected Treatments on Wall Shear Rates in Observed Venules and Systemic Leukocyte Concentration
| Experiment . | Treatment . | Wall Shear Rate . | Systemic (white blood cell) Cells/μL . |
|---|---|---|---|
| 30-minute surgical stimulation (P-selectin–dependent) | Control | 912 ± 98 | 7,000 ± 860 |
| sLex | 891 ± 87 | 6,400 ± 340 | |
| Control | 776 ± 112 | 3,800 ± 380 | |
| CGP69669A | 763 ± 91 | 4,600 ± 900 | |
| 60-minute surgical stimulation (L-, P-selectin–dependent) | Control | 749 ± 114 | 5,600 ± 1,027 |
| sLex | 856 ± 154 | 5,900 ± 850 | |
| Control | 550 ± 112 | 7,767 ± 1,332 | |
| CGP69669A | 578 ± 118 | 7,900 ± 1,906 | |
| TNFα-induced rolling (E-, L-, P-selectin–dependent) | Control | 577 ± 133 | 2,000 ± 115 |
| RB40.34 | 430 ± 53 | 1,900 ± 289 | |
| RB40.34 + sLex | 646 ± 45 | 2,000 ± 346 | |
| Control | 918 ± 332 | 1,400 ± 180 | |
| RB40.34 | 708 ± 210 | 1,500 ± 160 | |
| RB40.34 + CGP69669A | 909 ± 353 | 2,200 ± 340* |
| Experiment . | Treatment . | Wall Shear Rate . | Systemic (white blood cell) Cells/μL . |
|---|---|---|---|
| 30-minute surgical stimulation (P-selectin–dependent) | Control | 912 ± 98 | 7,000 ± 860 |
| sLex | 891 ± 87 | 6,400 ± 340 | |
| Control | 776 ± 112 | 3,800 ± 380 | |
| CGP69669A | 763 ± 91 | 4,600 ± 900 | |
| 60-minute surgical stimulation (L-, P-selectin–dependent) | Control | 749 ± 114 | 5,600 ± 1,027 |
| sLex | 856 ± 154 | 5,900 ± 850 | |
| Control | 550 ± 112 | 7,767 ± 1,332 | |
| CGP69669A | 578 ± 118 | 7,900 ± 1,906 | |
| TNFα-induced rolling (E-, L-, P-selectin–dependent) | Control | 577 ± 133 | 2,000 ± 115 |
| RB40.34 | 430 ± 53 | 1,900 ± 289 | |
| RB40.34 + sLex | 646 ± 45 | 2,000 ± 346 | |
| Control | 918 ± 332 | 1,400 ± 180 | |
| RB40.34 | 708 ± 210 | 1,500 ± 160 | |
| RB40.34 + CGP69669A | 909 ± 353 | 2,200 ± 340* |
Values are presented as the mean ± SEM of 3 or 4 mice per group.
Significantly different from control, P < .05.