Karyotype of AML or MDS in Children With and Without Down Syndrome (DS)
| Karyotype . | DS . | No DS . | P Value . | ||
|---|---|---|---|---|---|
| N . | % . | N . | % . | ||
| Normal/constitutional | 13 | (26) | 106 | (24) | .97 |
| t(8;21); t(15;17); 16q22 | 1 | (2) | 106 | (24) | <.001 |
| 11q23 | 3 | (6) | 62 | (14) | .15 |
| −7; 7q- | 2 | (4) | 26 | (6) | .79 |
| +8 | 7 | (14) | 29 | (7) | .12 |
| +21 | 4 | (8) | 9 | (2) | .05 |
| Hyperdiploid | 4 | (8) | 12 | (3) | .13 |
| Hypodiploid | 1 | (2) | 6 | (2) | .63 |
| Other | 16 | (31) | 81 | (19) | .04 |
| Karyotype . | DS . | No DS . | P Value . | ||
|---|---|---|---|---|---|
| N . | % . | N . | % . | ||
| Normal/constitutional | 13 | (26) | 106 | (24) | .97 |
| t(8;21); t(15;17); 16q22 | 1 | (2) | 106 | (24) | <.001 |
| 11q23 | 3 | (6) | 62 | (14) | .15 |
| −7; 7q- | 2 | (4) | 26 | (6) | .79 |
| +8 | 7 | (14) | 29 | (7) | .12 |
| +21 | 4 | (8) | 9 | (2) | .05 |
| Hyperdiploid | 4 | (8) | 12 | (3) | .13 |
| Hypodiploid | 1 | (2) | 6 | (2) | .63 |
| Other | 16 | (31) | 81 | (19) | .04 |
Results from 590 of 1,126 cases reviewed; 83% (488 of 590) were acceptable.