Some Discriminating Leukocyte Differentiation Antigens Expressed by Human DC
| Antigen/Molecule . | Blood DC (uncultured) . | DC activated/Differentiated* . | Blood Mo . | MØ . | Activated B Lymphocyte . |
|---|---|---|---|---|---|
| DC lineage | |||||
| CMRF-44 | (+) | +++ | ± | (+) | ++ |
| CMRF-56 | − | ++ | − | (+) | (+) |
| CD83 | − | + | − | − | (+) |
| DEC-205‡ | NAρ | ++ | NA | ± | ± |
| S100 | NA | ++ | ± | NA | − |
| Mo/MØ lineage | |||||
| CD14 | − | − | ++ | + | ± |
| CD68 | + | + | +++ | ++ | − |
| CD115 (M-CSFR) | − | − | ++ | + | − |
| Myeloid/lymphoid | ++ | ||||
| CD1 | − | (++)1-155 | − | (+) | − |
| CD4 | + | ± | + | + | − |
| CD5 | + | ++ | + | + | (+) |
| CD13 | + | + | + | + | − |
| CD33 | + | + | + | ± | − |
| Fc receptors | |||||
| CD64 | ± | − | ++ | ++ | − |
| CD32 | + | ± | ++ | ++ | + |
| CD16 | − | − | (+) | + | − |
| Adhesion molecules | |||||
| CD11a (LFA-1) | ++ | ++ | ++ | + | ++ |
| CD11b | − | (+) | ++ | + | − |
| CD11c | ± | ++ | + | + | (+) |
| ICAM-1 (CD54) | + | +++ | + | + | +++ |
| ICAM-2 (CD50) | + | + | |||
| ICAM-3 (CD102) | +++ | +++ | + | + | − |
| LFA-3 (CD58) | ++ | ++ | ++ | ++ | ++ |
| Costimulator molecules | |||||
| CD40 | ± | ++ | + | + | ++ |
| CD80 | − | ++ | − | + | ++ |
| CD86 | − | ++ | + | + | ++ |
| Leukocyte common | |||||
| CD45RA | + | ± | + | − | − |
| CD45RO | − | ++ | − | + | ++ |
| MHC | |||||
| HLA-ABC | ++ | +++ | + | ++ | ++ |
| HLA-DP | + | +++ | + | ++ | ++ |
| HLA-DQ | ++ | +++ | + | ++ | ++ |
| HLA-DR | ++ | +++ | + | ++ | ++ |
| Antigen/Molecule . | Blood DC (uncultured) . | DC activated/Differentiated* . | Blood Mo . | MØ . | Activated B Lymphocyte . |
|---|---|---|---|---|---|
| DC lineage | |||||
| CMRF-44 | (+) | +++ | ± | (+) | ++ |
| CMRF-56 | − | ++ | − | (+) | (+) |
| CD83 | − | + | − | − | (+) |
| DEC-205‡ | NAρ | ++ | NA | ± | ± |
| S100 | NA | ++ | ± | NA | − |
| Mo/MØ lineage | |||||
| CD14 | − | − | ++ | + | ± |
| CD68 | + | + | +++ | ++ | − |
| CD115 (M-CSFR) | − | − | ++ | + | − |
| Myeloid/lymphoid | ++ | ||||
| CD1 | − | (++)1-155 | − | (+) | − |
| CD4 | + | ± | + | + | − |
| CD5 | + | ++ | + | + | (+) |
| CD13 | + | + | + | + | − |
| CD33 | + | + | + | ± | − |
| Fc receptors | |||||
| CD64 | ± | − | ++ | ++ | − |
| CD32 | + | ± | ++ | ++ | + |
| CD16 | − | − | (+) | + | − |
| Adhesion molecules | |||||
| CD11a (LFA-1) | ++ | ++ | ++ | + | ++ |
| CD11b | − | (+) | ++ | + | − |
| CD11c | ± | ++ | + | + | (+) |
| ICAM-1 (CD54) | + | +++ | + | + | +++ |
| ICAM-2 (CD50) | + | + | |||
| ICAM-3 (CD102) | +++ | +++ | + | + | − |
| LFA-3 (CD58) | ++ | ++ | ++ | ++ | ++ |
| Costimulator molecules | |||||
| CD40 | ± | ++ | + | + | ++ |
| CD80 | − | ++ | − | + | ++ |
| CD86 | − | ++ | + | + | ++ |
| Leukocyte common | |||||
| CD45RA | + | ± | + | − | − |
| CD45RO | − | ++ | − | + | ++ |
| MHC | |||||
| HLA-ABC | ++ | +++ | + | ++ | ++ |
| HLA-DP | + | +++ | + | ++ | ++ |
| HLA-DQ | ++ | +++ | + | ++ | ++ |
| HLA-DR | ++ | +++ | + | ++ | ++ |
Based on summarized data referenced in text.
Cultured overnight or longer in the presence of serum. IDC downregulate CD11c, CD13, and CD33.
Key: −, negative; ±, variable; +, positive; ++, strong positive; +++, extremely strong; ( ), subset only positive.
Mouse data only at present
ρ NA, not available.
Langerhans cells.