Analysis of Clonal VH Sequences
| Patient . | Specimen . | No. Analyzed . | Most Similar Germline Segments . | Differences From Germline % (no.) . | |||
|---|---|---|---|---|---|---|---|
| V* . | D . | J . | Common† . | Noncommon . | |||
| MA | 1 | 2 | V3-7 | D21-9 | J3 | 0.3 (1) | 2.5 (16) |
| 2 | 3 | — | DXP′1 | — | 1.0 (3) | 1.2 (12) | |
| LE | 1 | 2 | 51p1 | DXP′1 | J4b | 5.9 (18) | 0.3 (2) |
| 2 | 2 | V3-7 | D21-9 | J3 | 2.9 (9) | 4.0 (26) | |
| JA | 1 | 3 | 7m27 | D21-9 | J4a | 0.94 (3) | 2.5 (25) |
| 2 | 4 | — | — | — | 1.9 (6) | 0.9 (12) | |
| PO | 1 | 3 | 51p1 | DA5 | J4a | 7.3 (20) | 0 |
| 2 | 3 | — | — | — | 6.6 (18) | 0 | |
| HA | 1 | 10 | 51p1 | D21-9/DIR3/DXP4 | J4b | 2.0 (6) | 0.2 (8) |
| 2 | 5 | — | — | — | 3.7 (12) | 0.3 (5) | |
| BA | 1 | 4 | 7m27 | DK4 | J3 | 3.7 (11) | 2.2 (28) |
| 2 | 5 | — | — | — | 7.6 (21) | 0 | |
| 2 | 3 | 51p1 | D21-9 | J4a | 4.1 (12) | 0.11 (1) | |
| OR | 1 | 6 | 7m27 | DIR4 | J4a | 7.2 (18) | 0 |
| 2 | 7 | 51p1 | D21-9 | J4a | 1.6 (5) | 0 | |
| Patient . | Specimen . | No. Analyzed . | Most Similar Germline Segments . | Differences From Germline % (no.) . | |||
|---|---|---|---|---|---|---|---|
| V* . | D . | J . | Common† . | Noncommon . | |||
| MA | 1 | 2 | V3-7 | D21-9 | J3 | 0.3 (1) | 2.5 (16) |
| 2 | 3 | — | DXP′1 | — | 1.0 (3) | 1.2 (12) | |
| LE | 1 | 2 | 51p1 | DXP′1 | J4b | 5.9 (18) | 0.3 (2) |
| 2 | 2 | V3-7 | D21-9 | J3 | 2.9 (9) | 4.0 (26) | |
| JA | 1 | 3 | 7m27 | D21-9 | J4a | 0.94 (3) | 2.5 (25) |
| 2 | 4 | — | — | — | 1.9 (6) | 0.9 (12) | |
| PO | 1 | 3 | 51p1 | DA5 | J4a | 7.3 (20) | 0 |
| 2 | 3 | — | — | — | 6.6 (18) | 0 | |
| HA | 1 | 10 | 51p1 | D21-9/DIR3/DXP4 | J4b | 2.0 (6) | 0.2 (8) |
| 2 | 5 | — | — | — | 3.7 (12) | 0.3 (5) | |
| BA | 1 | 4 | 7m27 | DK4 | J3 | 3.7 (11) | 2.2 (28) |
| 2 | 5 | — | — | — | 7.6 (21) | 0 | |
| 2 | 3 | 51p1 | D21-9 | J4a | 4.1 (12) | 0.11 (1) | |
| OR | 1 | 6 | 7m27 | DIR4 | J4a | 7.2 (18) | 0 |
| 2 | 7 | 51p1 | D21-9 | J4a | 1.6 (5) | 0 | |
*7m27 (also termed hv1051K) and 51p1 are closely related V1-69 alleles (see text). A dash indicates identity with the above sequence.
Common differences are those present in all of the VH sequences, whereas noncommon differences are present in only some of the VH sequences. Comparisons were made to the proposed germline V, D, and J segments.