Table 1. Total t-PA Before, During, and... | American Society of Hematology

Table 1.

Total t-PA Before, During, and After Placebo or 70 ng/min DDAVP Infusion

n = 7	Baseline*	Infusion			Postinfusion		ANOVA
n = 7	Baseline*	After 2 Min	After 4 Min	After 15 Min†	2 Min Rest	10 Min Rest	One-Way	Two-Way Placebo v DDAVP
Total t-PA
Arterial plasma concentration (ng/mL)
Placebo	5.58 (0.99)	6.04 (1.21)	5.87 (1.23)	6.12 (1.40)	5.86 (1.07)	6.26 (1.18)	NS	P = .053
DDAVP	5.27 (0.95)	5.42 (0.92)	5.57 (0.92)	6.26 (1.04)	5.93 (0.96)	6.18 (1.07)	P < .0001
Venous plasma concentration (ng/mL)
Placebo	6.24 (1.06)	6.18 (1.17)	6.39 (1.34)	6.56 (1.49)	6.17 (1.17)	6.53 (1.35)	NS	P < .0001
DDAVP	5.54 (0.94)	6.31 (0.94)	7.46 (1.02)	9.10 (1.23)	8.40 (1.00)	8.16 (1.16)	P < .0001
A-V concentration gradient (ng/mL)
Placebo	0.66 (0.13)	0.14 (0.06)	0.52 (0.18)	0.44 (0.21)	0.32 (0.26)	0.27 (0.27)	NS	P < .0001
DDAVP	0.28 (0.08)	0.89 (0.17)	1.89 (0.68)	2.84 (0.84)	2.47 (0.51)	1.98 (0.57)	P < .0001
Net release (ng × L⁻¹ × min⁻¹)
Placebo	11.1 (1.97)	2.41 (0.92)	8.54 (2.92)	8.00 (3.24)	4.91 (3.89)	5.11 (4.09)	NS	P < .0001
DDAVP	5.83 (2.63)	37.1 (11.4)	82.6 (36.1)	144 (58.0)	79.9 (23.8)	52.6 (16.1)	P < .0001
Active t-PA
Arterial plasma concentration (ng/mL)
Placebo	1.02 (0.15)	1.09 (0.15)	1.14 (0.15)	0.89 (0.22)	0.94 (0.20)	1.00 (0.22)	NS	P < .0001
DDAVP	0.98 (0.12)	1.08 (0.12)	1.14 (0.13)	1.35 (0.17)	1.34 (0.17)	1.25 (0.15)	P < .0001
Venous plasma concentration (ng/mL)
Placebo	1.23 (0.24)	1.30 (0.20)	1.29 (0.19)	1.22 (0.20)	1.27 (0.18)	1.28 (0.20)	NS	P < .0001
DDAVP	1.16 (0.16)	1.71 (0.24)	2.79 (0.58)	3.77 (0.71)	3.50 (0.46)	2.76 (0.45)	P < .0001
A-V concentration gradient (ng/mL)
Placebo	0.21 (0.09)	0.21 (0.06)	0.15 (0.05)	0.32 (0.18)	0.33 (0.16)	0.28 (0.15)	NS	P < .0001
DDAVP	0.19 (0.05)	0.64 (0.18)	1.65 (0.53)	2.42 (0.63)	2.15 (0.38)	1.50 (0.38)	P < .0001
Net release (ng × L⁻¹ × min⁻¹)
Placebo	3.92 (1.70)	3.34 (1.06)	2.60 (0.86)	4.69 (2.71)	5.98 (2.46)	4.33 (2.14)	NS	P < .0001
DDAVP	3.38 (1.18)	23.6 (9.44)	73.7 (28.9)	123 (44.3)	70.4 (18.3)	41.6 (12.4)	P < .0001

n = 7	Baseline*	Infusion			Postinfusion		ANOVA
n = 7	Baseline*	After 2 Min	After 4 Min	After 15 Min†	2 Min Rest	10 Min Rest	One-Way	Two-Way Placebo v DDAVP
Total t-PA
Arterial plasma concentration (ng/mL)
Placebo	5.58 (0.99)	6.04 (1.21)	5.87 (1.23)	6.12 (1.40)	5.86 (1.07)	6.26 (1.18)	NS	P = .053
DDAVP	5.27 (0.95)	5.42 (0.92)	5.57 (0.92)	6.26 (1.04)	5.93 (0.96)	6.18 (1.07)	P < .0001
Venous plasma concentration (ng/mL)
Placebo	6.24 (1.06)	6.18 (1.17)	6.39 (1.34)	6.56 (1.49)	6.17 (1.17)	6.53 (1.35)	NS	P < .0001
DDAVP	5.54 (0.94)	6.31 (0.94)	7.46 (1.02)	9.10 (1.23)	8.40 (1.00)	8.16 (1.16)	P < .0001
A-V concentration gradient (ng/mL)
Placebo	0.66 (0.13)	0.14 (0.06)	0.52 (0.18)	0.44 (0.21)	0.32 (0.26)	0.27 (0.27)	NS	P < .0001
DDAVP	0.28 (0.08)	0.89 (0.17)	1.89 (0.68)	2.84 (0.84)	2.47 (0.51)	1.98 (0.57)	P < .0001
Net release (ng × L⁻¹ × min⁻¹)
Placebo	11.1 (1.97)	2.41 (0.92)	8.54 (2.92)	8.00 (3.24)	4.91 (3.89)	5.11 (4.09)	NS	P < .0001
DDAVP	5.83 (2.63)	37.1 (11.4)	82.6 (36.1)	144 (58.0)	79.9 (23.8)	52.6 (16.1)	P < .0001
Active t-PA
Arterial plasma concentration (ng/mL)
Placebo	1.02 (0.15)	1.09 (0.15)	1.14 (0.15)	0.89 (0.22)	0.94 (0.20)	1.00 (0.22)	NS	P < .0001
DDAVP	0.98 (0.12)	1.08 (0.12)	1.14 (0.13)	1.35 (0.17)	1.34 (0.17)	1.25 (0.15)	P < .0001
Venous plasma concentration (ng/mL)
Placebo	1.23 (0.24)	1.30 (0.20)	1.29 (0.19)	1.22 (0.20)	1.27 (0.18)	1.28 (0.20)	NS	P < .0001
DDAVP	1.16 (0.16)	1.71 (0.24)	2.79 (0.58)	3.77 (0.71)	3.50 (0.46)	2.76 (0.45)	P < .0001
A-V concentration gradient (ng/mL)
Placebo	0.21 (0.09)	0.21 (0.06)	0.15 (0.05)	0.32 (0.18)	0.33 (0.16)	0.28 (0.15)	NS	P < .0001
DDAVP	0.19 (0.05)	0.64 (0.18)	1.65 (0.53)	2.42 (0.63)	2.15 (0.38)	1.50 (0.38)	P < .0001
Net release (ng × L⁻¹ × min⁻¹)
Placebo	3.92 (1.70)	3.34 (1.06)	2.60 (0.86)	4.69 (2.71)	5.98 (2.46)	4.33 (2.14)	NS	P < .0001
DDAVP	3.38 (1.18)	23.6 (9.44)	73.7 (28.9)	123 (44.3)	70.4 (18.3)	41.6 (12.4)	P < .0001

Values are the means, with the SEM in parentheses.

Abbreviation: NS, not significant.

F0-150

Mean of two samples.

F0-151

n = 6.

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