Available Hematologic and Globin Genotypes in Family Members Studied
| Subject . | RBC Count (×1012/L) . | Hb (g/dL) . | MCV (fL) . | MCH (pg) . | HbA2 (%) . | HbF (%) . | Reticulocytes (%) . | Ferritin (ng/mL) . | Non α/α . | Genotype . | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| α . | β . | ||||||||||
| III2 | 4.2 | 9.3-10.1 | 72 | 23.2 | 4.6 | 4.2 | — | 1,300 | — | αα/αα | βA/βthal |
| III3 | 4.2 | 7.7-9.0 | 65-66 | 20.0 | 4.2 | 1.7 | — | — | — | αα/αα | βA/βthal |
| III10 | — | 8.1 | 75 | — | 4.5 | 1.2 | — | — | — | αα/αα | βA/βthal |
| III13 | 4.3 | 9.6-11.4 | 66 | 20.7 | 4.0-4.6 | 1.8-2.1 | — | — | — | αα/αα | βA/βthal |
| III14 | 4.7 | 8.6-10.7 | 66-70 | 20.6 | 3.7 | 1.7-4.0 | 6 | 922 | — | ααα/αα | βA/βthal |
| III15 | — | 13.0 | 95 | — | 2.7 | 1.0 | — | — | 0.82 | αα/αα | βA/βA |
| IV3 | — | 8.7 | 75 | — | 3.8 | 4.8 | — | — | — | αα/αα | βA/βthal |
| IV6 | 4.6 | 9.0-10.4 | 64-68 | 21.2 | 5.0-5.4 | 0.8-0.9 | — | 241 | — | αα/αα | βA/βthal |
| IV7 | 3.9 | 8.7 | 76 | 21.9 | 3.9-5.0 | 4.5-4.7 | 4.7 | — | — | αα/αα | βA/βthal |
| IV14 | 4.1-4.4 | 9.6-9.7 | 76-78 | 21.6-23.8 | 4.7 | 3.5 | — | — | — | αα/αα | βA/βthal |
| IV16 | 4.6 | 16.2 | 101 | 35.6 | 2.8 | 0.7 | 2.5 | 120 | — | ααα/αα | βA/βA |
| IV17 | 5.0 | 17.1 | 99 | 34.5 | 1.7 | 0.3 | 0.6 | 235 | — | αα/αα | βA/βA |
| IV18 | 4.5 | 14.7 | 93 | 32.6 | 1.5 | 0.4 | 1.4 | 29.2 | — | ααα/αα | βA/βA |
| IV19 | 4.4 | 13.9 | 96 | 31.8 | 1.3 | 0.4 | 0.4 | 135 | — | ααα/αα | βA/βA |
| IV20 | 5.2 | 17.2 | 96 | 33.4 | 1.7 | 0.6 | 0.8 | 73.1 | — | ααα/αα | βA/βA |
| IV21 | 4.3 | 8.5-9.5 | 73 | 20.9 | 3.5-7.0 | 7.0 | 20.2 | 2,500 | 0.35 | ααα/αα | βA/βthal |
| IV22 | 4.8 | 7.6-9.3 | 68 | 22 | 4.0-5.8 | 4.5-7.0 | 4.5 | 175 | 0.41 | ααα/αα | βA/βthal |
| V6 | 3.3 | 7.3-7.6 | 72-76 | 23.0-23.9 | 4.8-5.1 | 4.0-5.2 | 2.2 | — | — | αα/αα | βA/βthal |
| Subject . | RBC Count (×1012/L) . | Hb (g/dL) . | MCV (fL) . | MCH (pg) . | HbA2 (%) . | HbF (%) . | Reticulocytes (%) . | Ferritin (ng/mL) . | Non α/α . | Genotype . | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| α . | β . | ||||||||||
| III2 | 4.2 | 9.3-10.1 | 72 | 23.2 | 4.6 | 4.2 | — | 1,300 | — | αα/αα | βA/βthal |
| III3 | 4.2 | 7.7-9.0 | 65-66 | 20.0 | 4.2 | 1.7 | — | — | — | αα/αα | βA/βthal |
| III10 | — | 8.1 | 75 | — | 4.5 | 1.2 | — | — | — | αα/αα | βA/βthal |
| III13 | 4.3 | 9.6-11.4 | 66 | 20.7 | 4.0-4.6 | 1.8-2.1 | — | — | — | αα/αα | βA/βthal |
| III14 | 4.7 | 8.6-10.7 | 66-70 | 20.6 | 3.7 | 1.7-4.0 | 6 | 922 | — | ααα/αα | βA/βthal |
| III15 | — | 13.0 | 95 | — | 2.7 | 1.0 | — | — | 0.82 | αα/αα | βA/βA |
| IV3 | — | 8.7 | 75 | — | 3.8 | 4.8 | — | — | — | αα/αα | βA/βthal |
| IV6 | 4.6 | 9.0-10.4 | 64-68 | 21.2 | 5.0-5.4 | 0.8-0.9 | — | 241 | — | αα/αα | βA/βthal |
| IV7 | 3.9 | 8.7 | 76 | 21.9 | 3.9-5.0 | 4.5-4.7 | 4.7 | — | — | αα/αα | βA/βthal |
| IV14 | 4.1-4.4 | 9.6-9.7 | 76-78 | 21.6-23.8 | 4.7 | 3.5 | — | — | — | αα/αα | βA/βthal |
| IV16 | 4.6 | 16.2 | 101 | 35.6 | 2.8 | 0.7 | 2.5 | 120 | — | ααα/αα | βA/βA |
| IV17 | 5.0 | 17.1 | 99 | 34.5 | 1.7 | 0.3 | 0.6 | 235 | — | αα/αα | βA/βA |
| IV18 | 4.5 | 14.7 | 93 | 32.6 | 1.5 | 0.4 | 1.4 | 29.2 | — | ααα/αα | βA/βA |
| IV19 | 4.4 | 13.9 | 96 | 31.8 | 1.3 | 0.4 | 0.4 | 135 | — | ααα/αα | βA/βA |
| IV20 | 5.2 | 17.2 | 96 | 33.4 | 1.7 | 0.6 | 0.8 | 73.1 | — | ααα/αα | βA/βA |
| IV21 | 4.3 | 8.5-9.5 | 73 | 20.9 | 3.5-7.0 | 7.0 | 20.2 | 2,500 | 0.35 | ααα/αα | βA/βthal |
| IV22 | 4.8 | 7.6-9.3 | 68 | 22 | 4.0-5.8 | 4.5-7.0 | 4.5 | 175 | 0.41 | ααα/αα | βA/βthal |
| V6 | 3.3 | 7.3-7.6 | 72-76 | 23.0-23.9 | 4.8-5.1 | 4.0-5.2 | 2.2 | — | — | αα/αα | βA/βthal |
Abbreviations: RBC, red blood cells; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin.