Published Cases of Acute Leukemia and MDS in ET Treated With HU (With or Without Other Drugs)
| First Author (Reference) . | FAB Type . | Treatment: Months . | Karyotype . |
|---|---|---|---|
| HU alone (19 cases) | |||
| Furgerson30 | M2 AML | HU: 126 | 47, XY, del(5)(q23),del(7)(q31),+8, inv(16)(p13;q22) |
| HU: 84 | 46, XY | ||
| Löfvenberg4 | MDS, | HU: 47 | 46, XX, t(3;21)(q25;p11) |
| M2 AML | HU: 17 | 44, XX,−5,−7,+der(7)−17 | |
| Anker-Lutenburg31 | MDS | HU: 84 | 46, XX |
| Murphy29 | M2 AML | HU: 38 | 46, XY, add(6)(p11),der(12)t(6;12)(p11;p13),add(18)(p11), der(20)t(12;20)(q13;q11) |
| Groupe Français de Cytogénétique Hématologue42 | UAL | HU: 24 | 46, XXi(17q) |
| Berkhan61 | ALL | HU: 9 | 46,XX |
| Liozon14 | M0 AML | HU: 64 | 46,XY, del(5)(q13;q34),del(7)(q22;q31),add(11)(q23),dic(11;16) (q23;q23), +r(11)(p15;q23),−17, der(21)t(21;22)(p13;q10),dmin |
| RAEB-T | HU: 92 | 43,X,−Y,−7,t(7,8)(q34;q22),t(7,12)(q34;q13), −11,dic(12,14) (q24;q12),−17,+mar | |
| Bellucci7 | M1 AML | HU: 43 | 46, XX |
| UAL | HU: 66 | ND | |
| Colombi13 | L2 ALL | HU: 36 | ND |
| Ferrari33 | M1 AML | HU: 6 | ND |
| Weinfeld34 | M2 AML | HU: 42 | ND |
| Turlure12 | ANLL | HU | ND |
| Nand52 | ND | HU | ND |
| Peterson15 | ND | HU | ND |
| Murphy29 | ND | HU | ND |
| HU and others drugs (15 cases) | |||
| Bellucci7 | UAL | HU, MEL,32P | ND |
| Woronzoff-Dashoff46 | B precursor | 32 P, HU: 47 | ND |
| ALL | |||
| Liozon14 | CMML | HU: 38, 6MP | 46,XY |
| Gris54 | M4 AML | HU: 22, MEL | ND |
| Peterson55 | |||
| 5 cases | ND | HU + MEL | ND |
| 1 case | ND | HU + 32P | ND |
| Murphy29 | |||
| 5 cases | ND | HU + 32P | ND |
| First Author (Reference) . | FAB Type . | Treatment: Months . | Karyotype . |
|---|---|---|---|
| HU alone (19 cases) | |||
| Furgerson30 | M2 AML | HU: 126 | 47, XY, del(5)(q23),del(7)(q31),+8, inv(16)(p13;q22) |
| HU: 84 | 46, XY | ||
| Löfvenberg4 | MDS, | HU: 47 | 46, XX, t(3;21)(q25;p11) |
| M2 AML | HU: 17 | 44, XX,−5,−7,+der(7)−17 | |
| Anker-Lutenburg31 | MDS | HU: 84 | 46, XX |
| Murphy29 | M2 AML | HU: 38 | 46, XY, add(6)(p11),der(12)t(6;12)(p11;p13),add(18)(p11), der(20)t(12;20)(q13;q11) |
| Groupe Français de Cytogénétique Hématologue42 | UAL | HU: 24 | 46, XXi(17q) |
| Berkhan61 | ALL | HU: 9 | 46,XX |
| Liozon14 | M0 AML | HU: 64 | 46,XY, del(5)(q13;q34),del(7)(q22;q31),add(11)(q23),dic(11;16) (q23;q23), +r(11)(p15;q23),−17, der(21)t(21;22)(p13;q10),dmin |
| RAEB-T | HU: 92 | 43,X,−Y,−7,t(7,8)(q34;q22),t(7,12)(q34;q13), −11,dic(12,14) (q24;q12),−17,+mar | |
| Bellucci7 | M1 AML | HU: 43 | 46, XX |
| UAL | HU: 66 | ND | |
| Colombi13 | L2 ALL | HU: 36 | ND |
| Ferrari33 | M1 AML | HU: 6 | ND |
| Weinfeld34 | M2 AML | HU: 42 | ND |
| Turlure12 | ANLL | HU | ND |
| Nand52 | ND | HU | ND |
| Peterson15 | ND | HU | ND |
| Murphy29 | ND | HU | ND |
| HU and others drugs (15 cases) | |||
| Bellucci7 | UAL | HU, MEL,32P | ND |
| Woronzoff-Dashoff46 | B precursor | 32 P, HU: 47 | ND |
| ALL | |||
| Liozon14 | CMML | HU: 38, 6MP | 46,XY |
| Gris54 | M4 AML | HU: 22, MEL | ND |
| Peterson55 | |||
| 5 cases | ND | HU + MEL | ND |
| 1 case | ND | HU + 32P | ND |
| Murphy29 | |||
| 5 cases | ND | HU + 32P | ND |
Abbreviations: UAL, undifferentiated acute leukemia; MDS, MDS of unspecified type; ALL, acute lymphocytic leukemia; ANLL, acute nonlymphocytic leukemia; CMML, chronic myelomonocytic leukemia; ND, not determined; MEL, melphalan; 6MP, 6-mercaptopurine.