Table 1.

Definition of Strategic Therapy Groups S1 to S4 in ALL-REZ BFM Relapse Trial Based on Time Point of Relapse, Site of Relapse, and Immunophenotype

Time Point Non-T Immunophenotype (Pre-)T Immunophenotype
Extramedullary BM Combined BM IsolatedExtramedullary BM Combined BM Isolated
Very early-150 S2  S4  S4  S2  S4  S4  
Early-151 S2 S2  S3  S2  S4  S4  
Late-152 S1  S2  S2 S1  S4  S4 
Time Point Non-T Immunophenotype (Pre-)T Immunophenotype
Extramedullary BM Combined BM IsolatedExtramedullary BM Combined BM Isolated
Very early-150 S2  S4  S4  S2  S4  S4  
Early-151 S2 S2  S3  S2  S4  S4  
Late-152 S1  S2  S2 S1  S4  S4 

Abbreviation: BM, bone marrow.

F0-150

Not late and date of relapse diagnosis minus date of previous diagnosis <18 months.

F0-151

Not late and date of relapse diagnosis minus date of previous diagnosis ≥18 months.

F0-152

Date of relapse diagnosis minus date of cessation of previous therapy ≥6 months.

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