Summary of Clinical Laboratory Parameters of DEGR VIIa-Treated and Control Groups
| Observations . | T-0 . | T + 1 h . | T + 2 h . | T + 4 h . | T + 6 h . | T + 8 h . |
|---|---|---|---|---|---|---|
| LD100E coli plus DEGR VIIa | ||||||
| MSAP (mm Hg) | 110 ± 3 | 102 ± 5 | 63 ± 6 | 58 ± 4* | 73 ± 4* | 74 ± 3* |
| Inflammatory | ||||||
| WBC (×103/μL) | 5.0 ± 0.6 | 1.4 ± 0.1 | 1.1 ± 0.1 | 1.3 ± 0.2 | 1.5 ± 0.2 | 2.0 ± 0.4 |
| Hemostasis | ||||||
| Hematocrit (mm) | 39 ± 0.4 | 38 ± 1.0 | 37 ± 1.0 | 38 ± 1.1 | 40 ± 1.1 | 40 ± 1.0 |
| Platelets (%) | 100 | 76 ± 5.1 | 65 ± 8.3 | 70 ± 10.1 | 66 ± 6.8* | 60 ± 6.1* |
| Fibrinogen (%) | 100 | 92 ± 3.7 | 83 ± 2.8 | 80 ± 2.7* | 76 ± 3.4* | 77 ± 4.0* |
| FDP (μg/dL) | <10 | — | — | — | — | 34 ± 21* |
| Cell injury | ||||||
| BUN (mg/dL) | 17.8 ± 1.4 | — | — | — | — | 27.4 ± 1.0 |
| CR (mg/dL) | 0.53 ± 0.03 | — | — | — | — | 1.2 ± 0.2 |
| SGPT (U/L) | 37 ± 3 | — | — | — | — | 190 ± 97 |
| Renal path (0-4+) | — | — | — | — | — | 0.05 ± 0.1* |
| LD100E coli alone | ||||||
| MSAP (mm Hg) | 116 ± 9 | 118 ± 7 | 69 ± 8 | 74 ± 4 | 83 ± 4 | 84 ± 4 |
| Inflammatory | ||||||
| WBC (×103/μL) | 6.3 ± 1.1 | 1.8 ± 0.3 | 1.1 ± 0.2 | 1.2 ± 0.2 | 1.6 ± 0.3 | 2.4 ± 0.5 |
| Hemostasis | ||||||
| Hematocrit (mm) | 40 ± 0.1 | 42 ± 1.0 | 39 ± 1.1 | 40 ± 1.9 | 42 ± 1.5 | 42 ± 1.4 |
| Platelets (%) | 100 | 72 ± 7.2 | 60 ± 9.1 | 51 ± 6.7 | 43 ± 5.5 | 34 ± 4.5 |
| Fibrinogen (%) | 100 | 89 ± 5.1 | 63 ± 10 | 13 ± 7.9 | 6.2 ± 5.8 | 7 ± 5.7 |
| FDP (μg/dL) | <10 | — | — | — | — | 311 ± 84 |
| Cell injury | ||||||
| BUN (mg/dL) | 18 ± 3.1 | — | — | — | — | 25 ± 2.4 |
| CR (mg/dL) | 0.65 ± 0.02 | — | — | — | — | 2.0 ± 0.3 |
| SGPT (U/L) | 36 ± 6 | — | — | — | — | 104 ± 32 |
| Renal Path (0-4+) | — | — | — | — | — | 3.2 ± 0.4 |
| Observations . | T-0 . | T + 1 h . | T + 2 h . | T + 4 h . | T + 6 h . | T + 8 h . |
|---|---|---|---|---|---|---|
| LD100E coli plus DEGR VIIa | ||||||
| MSAP (mm Hg) | 110 ± 3 | 102 ± 5 | 63 ± 6 | 58 ± 4* | 73 ± 4* | 74 ± 3* |
| Inflammatory | ||||||
| WBC (×103/μL) | 5.0 ± 0.6 | 1.4 ± 0.1 | 1.1 ± 0.1 | 1.3 ± 0.2 | 1.5 ± 0.2 | 2.0 ± 0.4 |
| Hemostasis | ||||||
| Hematocrit (mm) | 39 ± 0.4 | 38 ± 1.0 | 37 ± 1.0 | 38 ± 1.1 | 40 ± 1.1 | 40 ± 1.0 |
| Platelets (%) | 100 | 76 ± 5.1 | 65 ± 8.3 | 70 ± 10.1 | 66 ± 6.8* | 60 ± 6.1* |
| Fibrinogen (%) | 100 | 92 ± 3.7 | 83 ± 2.8 | 80 ± 2.7* | 76 ± 3.4* | 77 ± 4.0* |
| FDP (μg/dL) | <10 | — | — | — | — | 34 ± 21* |
| Cell injury | ||||||
| BUN (mg/dL) | 17.8 ± 1.4 | — | — | — | — | 27.4 ± 1.0 |
| CR (mg/dL) | 0.53 ± 0.03 | — | — | — | — | 1.2 ± 0.2 |
| SGPT (U/L) | 37 ± 3 | — | — | — | — | 190 ± 97 |
| Renal path (0-4+) | — | — | — | — | — | 0.05 ± 0.1* |
| LD100E coli alone | ||||||
| MSAP (mm Hg) | 116 ± 9 | 118 ± 7 | 69 ± 8 | 74 ± 4 | 83 ± 4 | 84 ± 4 |
| Inflammatory | ||||||
| WBC (×103/μL) | 6.3 ± 1.1 | 1.8 ± 0.3 | 1.1 ± 0.2 | 1.2 ± 0.2 | 1.6 ± 0.3 | 2.4 ± 0.5 |
| Hemostasis | ||||||
| Hematocrit (mm) | 40 ± 0.1 | 42 ± 1.0 | 39 ± 1.1 | 40 ± 1.9 | 42 ± 1.5 | 42 ± 1.4 |
| Platelets (%) | 100 | 72 ± 7.2 | 60 ± 9.1 | 51 ± 6.7 | 43 ± 5.5 | 34 ± 4.5 |
| Fibrinogen (%) | 100 | 89 ± 5.1 | 63 ± 10 | 13 ± 7.9 | 6.2 ± 5.8 | 7 ± 5.7 |
| FDP (μg/dL) | <10 | — | — | — | — | 311 ± 84 |
| Cell injury | ||||||
| BUN (mg/dL) | 18 ± 3.1 | — | — | — | — | 25 ± 2.4 |
| CR (mg/dL) | 0.65 ± 0.02 | — | — | — | — | 2.0 ± 0.3 |
| SGPT (U/L) | 36 ± 6 | — | — | — | — | 104 ± 32 |
| Renal Path (0-4+) | — | — | — | — | — | 3.2 ± 0.4 |
*Denotes those values of the treated group that differ significantly from those of the control group (Pvalue ≥ .05).