Distribution and Allele Frequency of TNF (−308) and LTα (+252) Polymorphisms Among 96 Healthy Controls and 273 Patients With NHL, Including 85 Patients With Available Cytokines' Plasma Levels at the Time of Diagnosis
| . | Allele Frequency . | Genotype Distribution . | |||
|---|---|---|---|---|---|
| TNF1 . | TNF2 . | TNF1/1 . | TNF1/2 . | TNF2/2 . | |
| Controls | 0.84 | 0.16 | 69 (72%) | 24 (25%) | 3 (3%) |
| Patients | 0.86 | 0.14 | 203 (74%) | 65 (24%) | 5 (2%) |
| TNF ≤33.0 pg/mL | 0.94 | 0.06 | 38 (90%) | 3 (7%) | 1 (2%) |
| TNF >33.0 pg/mL | 0.83 | 0.17 | 28 (65%) | 15 (35%) | 0 |
| LTα (10.5) | LTα (5.5) | LTα (10.5/10.5) | (10.5/5.5) | (5.5/5.5) | |
| Controls | 0.70 | 0.30 | 48 (50%) | 38 (40%) | 10 (10%) |
| Patients | 0.71 | 0.29 | 140 (51%) | 110 (40%) | 23 (9%) |
| LTα ≤10.0 pg/mL | 0.73 | 0.27 | 22 (53%) | 17 (40%) | 3 (7%) |
| LTα >10.0 pg/mL | 0.66 | 0.34 | 19 (44%) | 19 (44%) | 5 (12%) |
| . | Allele Frequency . | Genotype Distribution . | |||
|---|---|---|---|---|---|
| TNF1 . | TNF2 . | TNF1/1 . | TNF1/2 . | TNF2/2 . | |
| Controls | 0.84 | 0.16 | 69 (72%) | 24 (25%) | 3 (3%) |
| Patients | 0.86 | 0.14 | 203 (74%) | 65 (24%) | 5 (2%) |
| TNF ≤33.0 pg/mL | 0.94 | 0.06 | 38 (90%) | 3 (7%) | 1 (2%) |
| TNF >33.0 pg/mL | 0.83 | 0.17 | 28 (65%) | 15 (35%) | 0 |
| LTα (10.5) | LTα (5.5) | LTα (10.5/10.5) | (10.5/5.5) | (5.5/5.5) | |
| Controls | 0.70 | 0.30 | 48 (50%) | 38 (40%) | 10 (10%) |
| Patients | 0.71 | 0.29 | 140 (51%) | 110 (40%) | 23 (9%) |
| LTα ≤10.0 pg/mL | 0.73 | 0.27 | 22 (53%) | 17 (40%) | 3 (7%) |
| LTα >10.0 pg/mL | 0.66 | 0.34 | 19 (44%) | 19 (44%) | 5 (12%) |
Cytokines' plasma levels equal to or lower versus higher than median values observed in NHL patients.