Inhibition of APC and Thrombin by PCI in the Absence or Presence of Rabbit Lung TM or Human TM4-6
| . | PCI (M−1 s−1) . | PCI + TM (M−1 s−1) . | Stimulation (fold) . | PCI + TM4-6 (M−1s−1) . | Stimulation (fold) . |
|---|---|---|---|---|---|
| APC | 2.1 × 103 | 4.6 × 103 | 2.2 | ND | |
| Thrombin | 3.7 × 104 | 1.22 × 106 | 33 | 8.8 × 105 | 24 |
| . | PCI (M−1 s−1) . | PCI + TM (M−1 s−1) . | Stimulation (fold) . | PCI + TM4-6 (M−1s−1) . | Stimulation (fold) . |
|---|---|---|---|---|---|
| APC | 2.1 × 103 | 4.6 × 103 | 2.2 | ND | |
| Thrombin | 3.7 × 104 | 1.22 × 106 | 33 | 8.8 × 105 | 24 |
Second order-rate inactivation constants were derived as described in Materials and Methods. Each value represents the average of at least three independent determinations.
Abbreviation: ND, not determined.