Effect of Vitamin C Supplementation on Leukocyte Ascorbic Acid Levels and Indirect Serum Measurements of Iron Status
| Parameter . | No. of Subjects . | Day 1 . | Day 2 . | Day 3 . | F . | P . |
|---|---|---|---|---|---|---|
| Ascorbic acid (μg/108 leukocytes, mean ± SD) | 298 | 26.8 ± 14.8 | 30.8 ± 16.3 | 32.0 ± 16.9 | 43.0 | <.001 |
| Transferrin saturation (%, mean ± SD) | 322 | 45 ± 25 | 45 ± 26 | 45 ± 26 | 0.3 | .58 |
| Unsaturated iron binding capacity (μg/dL, mean ± SD) | 322 | 166 ± 92 | 168 ± 96 | 163 ± 93 | 0.9 | .34 |
| Serum ferritin (μg/L, geometric mean and SD range) | 322 | 211 (35-1,279) | 214 (37-1,245) | 212 (36-1,253) | 0.2 | .78 |
| Parameter . | No. of Subjects . | Day 1 . | Day 2 . | Day 3 . | F . | P . |
|---|---|---|---|---|---|---|
| Ascorbic acid (μg/108 leukocytes, mean ± SD) | 298 | 26.8 ± 14.8 | 30.8 ± 16.3 | 32.0 ± 16.9 | 43.0 | <.001 |
| Transferrin saturation (%, mean ± SD) | 322 | 45 ± 25 | 45 ± 26 | 45 ± 26 | 0.3 | .58 |
| Unsaturated iron binding capacity (μg/dL, mean ± SD) | 322 | 166 ± 92 | 168 ± 96 | 163 ± 93 | 0.9 | .34 |
| Serum ferritin (μg/L, geometric mean and SD range) | 322 | 211 (35-1,279) | 214 (37-1,245) | 212 (36-1,253) | 0.2 | .78 |
One to 2 g vitamin C was administered orally 24 hours before the day 2 blood sample and 24 hours before the day 3 sample were collected. Statistical analysis was performed with repeated-measures analysis of variance.