Hydrophobic Distances (Å) Between Two Hydrophobic Amino Acid Residues
| . | PC408 (Å) . | PC410 (Å) . | PC412 (Å) . | Trypsin* (Å) . | Average and Standard Deviation of 13 Serine Proteases . |
|---|---|---|---|---|---|
| I407Cγ2-W205Cγ | 3.6 | 3.44 | 3.74 | 4.46 | 3.76 ± 0.41 |
| I403Cγ2-I201Cδ1 | 3.85 | 3.58 | 3.7 | 3.71 | 4.2 ± 0.68 |
| I403Cδ2-L278Cδ2 | 5 | 4.94 | 4.94 | 4.97 | 3.97 ± 0.36 |
| Y399Cδ2-I258Cγ1 | 3.47 | 3.52 | 4.86 | 5.15 | 3.74 ± 0.24 |
| . | PC408 (Å) . | PC410 (Å) . | PC412 (Å) . | Trypsin* (Å) . | Average and Standard Deviation of 13 Serine Proteases . |
|---|---|---|---|---|---|
| I407Cγ2-W205Cγ | 3.6 | 3.44 | 3.74 | 4.46 | 3.76 ± 0.41 |
| I403Cγ2-I201Cδ1 | 3.85 | 3.58 | 3.7 | 3.71 | 4.2 ± 0.68 |
| I403Cδ2-L278Cδ2 | 5 | 4.94 | 4.94 | 4.97 | 3.97 ± 0.36 |
| Y399Cδ2-I258Cγ1 | 3.47 | 3.52 | 4.86 | 5.15 | 3.74 ± 0.24 |
Hydrophobic distances (Å) in the hydrophobic core in relation to the alpha-helix with three rounds from Y399 to K410 in PC408, PC410, PC412, bovine beta-trypsin, and average and standard deviation of 13 serine proteases, which are 1TLD (bovine beta-trypsin), 1PFX (porcine factor IXa), 1TRN (human trypsin), 1PPB (human alpha-thrombin), 1HCG (human coagulation factor Xa), 1LMW (human urokinase-type plasminogen activator), 5CHA (bovine alpha-chymotrypsin A), 2PKA (porcine kallikrein A), 3EST (porcine pancreas elastase), 3RP2 (rat mast cell protease), 1HNE (human leukocyte elastase), 1TON (rat tonin), and 1FUJ (a neutrophil serine protease antigen of Wegener's granulomatosis antibodies) in the Protein Data Bank. The nearest distance between two hydrophobic amino acid residues is defined as the hydrophobic distance.
Amino acids number is described by protein C numbering. The alignment was shown previously.11