Table 3.

Inhibition of IgE-Induced Upregulation of FcRIα by Antibody CGP51901 in Cultured Basophils

Experiment No. Day 0Day 7
Control 51901 IgE*IgE + CGP51901
1  89† 86  89  132  89 
2  56  48  37   80  45  
3  98  64  57 103  64  
 
Average fold upregulation  (1.00) 0.82 ± .09  0.75 ± .13  1.32 ± .14 0.83 ± .10 
Experiment No. Day 0Day 7
Control 51901 IgE*IgE + CGP51901
1  89† 86  89  132  89 
2  56  48  37   80  45  
3  98  64  57 103  64  
 
Average fold upregulation  (1.00) 0.82 ± .09  0.75 ± .13  1.32 ± .14 0.83 ± .10 

CGP51901 = chimeric monoclonal anti-IgE antibody at 10 μg/mL.

*

IgE = PS myeloma at 500 ng/mL.

†

Listed values are net fluorescence units for monoclonal antibody 22E7 binding as determined by flow cytometry; average data are calculated as fold upregulation using day 0 values as the reference point for each experiment.

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