Hydroxyurea Pharmacokinetic Parameters and Bioavailability
| Mean Pharmacokinetic Parameters (± SD) . | Oral (n = 26) . | intravenous (n = 25) . |
|---|---|---|
| Cmax (μmol/L) | 793.75 (240.89) | 1,006.65 (371.00) |
| Absorption | ||
| Tmax (h) | 1.22 (1.22) | |
| ka (h−1) | 3.20 (5.87) | |
| T1/2a (h)* | 0.53 (0.37) | |
| Tlag (h) | 0.22 (0.16) | |
| MAT (min) | 0.72 (0.55) | |
| Bioavailability (%; n = 22) | 108.09 (18.56) | |
| MRT (h)* | 5.45 (1.02) | 4.79 (1.01) |
| T1/2α(h)* | 1.78 (1.60) | 0.63 (1.26) |
| T1/2β (h)* | 3.32 (0.84) | 3.39 (0.73) |
| AUC (μmol/L/hr)† | 3,759 (1,127) | 3,626 (1,155) |
| AUC (μmol/L/hr)‡ | 3,934 (1,096) | 3,552 (1,181) |
| AUMC (μmol/L/hr2) | 21,425 (7,381) | 19,512 (8,656) |
| VSS,oral F (L/m2) | 19.65 (4.73) | |
| VSS,iv (L/m2) | 19.71 (4.57) | |
| Cliv | ||
| (mL/min) | 106 (62.33) | |
| (mL/min/m2) | 72.16 (17.33) | |
| Cl/Foral | ||
| (mL/min) | 124.83 (54.66) | |
| (mL/min/m2) | 73.16 (16.66) | |
| Renal excretion (%) | 36.24 (7.57) | 35.82 (14.16) |
| Mean Pharmacokinetic Parameters (± SD) . | Oral (n = 26) . | intravenous (n = 25) . |
|---|---|---|
| Cmax (μmol/L) | 793.75 (240.89) | 1,006.65 (371.00) |
| Absorption | ||
| Tmax (h) | 1.22 (1.22) | |
| ka (h−1) | 3.20 (5.87) | |
| T1/2a (h)* | 0.53 (0.37) | |
| Tlag (h) | 0.22 (0.16) | |
| MAT (min) | 0.72 (0.55) | |
| Bioavailability (%; n = 22) | 108.09 (18.56) | |
| MRT (h)* | 5.45 (1.02) | 4.79 (1.01) |
| T1/2α(h)* | 1.78 (1.60) | 0.63 (1.26) |
| T1/2β (h)* | 3.32 (0.84) | 3.39 (0.73) |
| AUC (μmol/L/hr)† | 3,759 (1,127) | 3,626 (1,155) |
| AUC (μmol/L/hr)‡ | 3,934 (1,096) | 3,552 (1,181) |
| AUMC (μmol/L/hr2) | 21,425 (7,381) | 19,512 (8,656) |
| VSS,oral F (L/m2) | 19.65 (4.73) | |
| VSS,iv (L/m2) | 19.71 (4.57) | |
| Cliv | ||
| (mL/min) | 106 (62.33) | |
| (mL/min/m2) | 72.16 (17.33) | |
| Cl/Foral | ||
| (mL/min) | 124.83 (54.66) | |
| (mL/min/m2) | 73.16 (16.66) | |
| Renal excretion (%) | 36.24 (7.57) | 35.82 (14.16) |