Clinical Features of Patients With Nonhepatosplenic γδ T-Cell Lymphomas
| Case No. . | Age/ Sex . | Past History . | Initial Symptoms . | Initial Site of Involvement . | Initial Staging . | Sites of Involvement During Clinical Course . | Treatment/ Outcome . | |
|---|---|---|---|---|---|---|---|---|
| H/S . | LN/BM . | |||||||
| 1 | 30/M | RMS | Ulcerative lesions of the upper respiratory tract, fever | Nasal cavity | −/− | −/− | Nasal recurrence liver, spleen, cervical LN | CT (CHOP) DOD after 5 mo (hepatic failure) |
| 2 | 62/F | RMS | Nasal obstruction, periorbital edema, fever | Nasal cavity | −/− | −/− | Nasal recurrence bone marrow | CT (CHOP + RT) DOD after 12 mo |
| 3 | 56/M | RMS | Nasal obstruction, epistaxis | Nasal cavity | −/− | −/− | — | CT (ACVBP) NOD after 21 mo |
| 4 | 65/F | Pneumocystis, CMV infection, UCID | Cough, fever, pulmonary opacities | Lung | −/− | −/− | Pulmonary recurrence | CT (CHOP) DOD after 12 mo |
| 5 | 88/M | — | Dysphonia, weight loss | Larynx | −/− | −/ND | Skin, liver, spleen abdominal LN | Oral CT (CLB) DOD after 10 mo |
| 6 | 45/F | CHP | Cutaneous nodule of the left thigh, fever | Skin | −/− | −/− | Skin recurrence, lung, liver, spleen | CT (CHOP) DOD after 17 mo |
| 7 | 14/M | CHP | Cutaneous nodule of the left buttock, fever, weight loss | Skin | −/− | −/− | Local subcutaneous progression | CT (CHOP) Alive after 1 mo |
| 8 | 41/M | Spontaneous regressive skin eruptions | Multiple ulcerative necrotic cutaneous nodules | Skin | −/− | −/− | Skin recurrence | CT (Pro-Mace Cyta bom), RT, alive after 8 years |
| 9 | 53/M | Resistant strongyloidiasis, HTLV-1+ | Epigastric pain, fever | Stomach | −/− | −/− | Gastric recurrence liver, spleen, abdominal LN | CT (CHOP, DHAP), PSC transplantation NOD after 24 mo |
| 10 | 43/M | — | Peritonitis (intestinal perforation), fever, weight loss | Small bowel | −/− | −/− | — | CT (CHOP) DOD after 2 mo |
| 11 | 38/M | Celiac sprue | Abdominal pain | Small bowel | −/− | −/− | — | CT (AVmCP) Alive after 3 mo |
| Case No. . | Age/ Sex . | Past History . | Initial Symptoms . | Initial Site of Involvement . | Initial Staging . | Sites of Involvement During Clinical Course . | Treatment/ Outcome . | |
|---|---|---|---|---|---|---|---|---|
| H/S . | LN/BM . | |||||||
| 1 | 30/M | RMS | Ulcerative lesions of the upper respiratory tract, fever | Nasal cavity | −/− | −/− | Nasal recurrence liver, spleen, cervical LN | CT (CHOP) DOD after 5 mo (hepatic failure) |
| 2 | 62/F | RMS | Nasal obstruction, periorbital edema, fever | Nasal cavity | −/− | −/− | Nasal recurrence bone marrow | CT (CHOP + RT) DOD after 12 mo |
| 3 | 56/M | RMS | Nasal obstruction, epistaxis | Nasal cavity | −/− | −/− | — | CT (ACVBP) NOD after 21 mo |
| 4 | 65/F | Pneumocystis, CMV infection, UCID | Cough, fever, pulmonary opacities | Lung | −/− | −/− | Pulmonary recurrence | CT (CHOP) DOD after 12 mo |
| 5 | 88/M | — | Dysphonia, weight loss | Larynx | −/− | −/ND | Skin, liver, spleen abdominal LN | Oral CT (CLB) DOD after 10 mo |
| 6 | 45/F | CHP | Cutaneous nodule of the left thigh, fever | Skin | −/− | −/− | Skin recurrence, lung, liver, spleen | CT (CHOP) DOD after 17 mo |
| 7 | 14/M | CHP | Cutaneous nodule of the left buttock, fever, weight loss | Skin | −/− | −/− | Local subcutaneous progression | CT (CHOP) Alive after 1 mo |
| 8 | 41/M | Spontaneous regressive skin eruptions | Multiple ulcerative necrotic cutaneous nodules | Skin | −/− | −/− | Skin recurrence | CT (Pro-Mace Cyta bom), RT, alive after 8 years |
| 9 | 53/M | Resistant strongyloidiasis, HTLV-1+ | Epigastric pain, fever | Stomach | −/− | −/− | Gastric recurrence liver, spleen, abdominal LN | CT (CHOP, DHAP), PSC transplantation NOD after 24 mo |
| 10 | 43/M | — | Peritonitis (intestinal perforation), fever, weight loss | Small bowel | −/− | −/− | — | CT (CHOP) DOD after 2 mo |
| 11 | 38/M | Celiac sprue | Abdominal pain | Small bowel | −/− | −/− | — | CT (AVmCP) Alive after 3 mo |
Abbreviations: M, male; F, female; RMS, recurrent maxillary sinusitis; DOD, dead of disease; NOD, no evidence of disease; CT, chemotherapy; RT, radiotherapy; UCID, unclassified immunodeficiency; H/S, hepatosplenic; LN/BM, lymph node/bone marrow; ND, not done; PSC, peripheral stem cell; C, cyclophosphamide; H,A doxorubicin; O,V, vincristine; P, prednisone; B, bleomycin; CLB, chlorambucil; CHP, cytophagic histiocytic panniculitis.