Hematologic and Cytogenetic Findings in 17 MDS and AML Patients With 17p Deletion
| Patient No. . | Sex/Age . | Therapy Related . | FAB Type . | “Typical” Dysgranulopoiesis-151 . | Conventional Cytogenetic Findings . |
|---|---|---|---|---|---|
| t(5;17) translocation | |||||
| 1 | F/63 | No | M1AML | Yes | 43,XX,del(2)(p13),−3,del(5)(q11q23),der(5)t(5;17)(q23;q11),del(6)(p21), −7,add(9)(p13),add(12)(p11),del(15)(q15),−17 [17] /46,XX [1] |
| 2* | M/40 | No | RAEB-T | Yes | 42,XY,−3,−4,−5,−7,−11,−12,−16, der(17)t(5;17)(p11;p11),−20,+4mar [22] /46,XY [4] |
| 3 | M/71 | Yes | RAEB | Yes | 45,XY,−5, r(7), der(17)t(5;17)(p11;p12),+mar1 [7] /45,idem,del(3)(p13) [3] /46,XY [3] |
| 4 | M/68 | Yes | RAEB | Yes | 44,X,−Y,−3,−5,der(5)t(3;5)(p13;q31),der(17)t(5;17)(p11;p11),−18,+r, +mar [20] |
| 5 | M/75 | Yes | M2AML | Yes | 45,XY,−5, der(17)t inv(5;17)(p11q14;p11) [15] /46,XY [2] |
| 6 | M/82 | Yes | RAEB-T | Yes | 45,XY,−5, der(17)t(5;17)(p11;p11) [9] /46,idem,+8 [3] /45,XY,−5,add(16)(q21),−17,der(18)t(17;18)(q11;q23),+mar [1] |
| 7* | F/67 | Yes | RAEB | Yes | 44,XX,−5,−7, der(17)t(5;17)(p11;p11) [11] |
| 8 | M/57 | No | RAEB | No | 43-44,XY,add(2)(p11),−5,add(5)(p1?),der(5)t(5;17)(q13;q11),−7,−13,−17, del(20)(q12),−21,+(0-1)r,+mar1,+mar2 [7] |
| 9 | M/69 | No | RAEB | No | 44-46,XY, der(5)t(5;17)(q11;q11),del(7)(q21q34),+i(8)(q10), dup(13)(q11p13), ?add(16)(q11),−17,−(0-1)18,−21,+r [15] /46,XY [1] |
| Rearrangement between 17p and another chromosome | |||||
| 10 | M/62 | Yes | M5AML | Not evaluable | 44-46,XY,(0-1)add(2)(q35),der(7)t(1;7)(p11;p21),+(0-1)i(8)(q10), t(9;11)(p21;q23),−12,−(0-1)13,der(17)t(12;17)(q11;p11), (0-1)add(22)(p11),+(0-1)mar,(1-2)dmin(cp7) [16] |
| 11* | M/76 | No | RAEB-T | Yes | 43-45,XY,3,add(5)(p?),del(5)(q14q32),+11,add(11)(q23), der(12)t(12;17)(p12;q11),del(13)(q13q14),−17,−22,+mar,ace [cp4] |
| 12 | F/81 | No | M2AML | Yes | 41-42,XX,del(4)(q13),−5,der(9)t(9;10)(p21;q11),−12,t(13;15)(p10;p10), −15,add(16)(q11),der(17)t(17;21)(p11;q11),?i(21)(q10),−21,−22,add(22)(p11), +(1-3)mar [18] /46,XX [1] |
| 13 | F/75 | Yes | M2AML | Yes | 44-45,XX,del(5)(q11q34),−17, add(17)(p13), −18,t(?21;22)(q22;q11), mar(15),+mar1 [8] |
| 14 | F/71 | No | RAEB | Yes | 46-49,XX,del(5)(q13q33),−7,del(9)(q23q32), add(17)(p11), −18, (0-1)del(20)(q11),−21,+22,+(2-4)mar [11] /46,XX,del(5)(q13;q33) [1] /46,XX [2] |
| 15 | M/47 | Yes | RAEB | Yes | 44-45,XY,−(0-1)7,add(12)(p12),−(0-1)15, add(17)(p11), add(21)(q13), +(0-1)mar [22] |
| Monosomy 17 and i(17q) | |||||
| 16 | M/55 | Yes | M2AML | Yes | 45,XY,del(5)(q13,q33),del(11)(p12),add(15)(q23),−16,−17,−20, +mar1,+mar( cp7) [13] |
| 17 | M/68 | No | RAEB | Yes | 46,XY,i(17)(q10) [14] /46,XY [3] |
| Patient No. . | Sex/Age . | Therapy Related . | FAB Type . | “Typical” Dysgranulopoiesis-151 . | Conventional Cytogenetic Findings . |
|---|---|---|---|---|---|
| t(5;17) translocation | |||||
| 1 | F/63 | No | M1AML | Yes | 43,XX,del(2)(p13),−3,del(5)(q11q23),der(5)t(5;17)(q23;q11),del(6)(p21), −7,add(9)(p13),add(12)(p11),del(15)(q15),−17 [17] /46,XX [1] |
| 2* | M/40 | No | RAEB-T | Yes | 42,XY,−3,−4,−5,−7,−11,−12,−16, der(17)t(5;17)(p11;p11),−20,+4mar [22] /46,XY [4] |
| 3 | M/71 | Yes | RAEB | Yes | 45,XY,−5, r(7), der(17)t(5;17)(p11;p12),+mar1 [7] /45,idem,del(3)(p13) [3] /46,XY [3] |
| 4 | M/68 | Yes | RAEB | Yes | 44,X,−Y,−3,−5,der(5)t(3;5)(p13;q31),der(17)t(5;17)(p11;p11),−18,+r, +mar [20] |
| 5 | M/75 | Yes | M2AML | Yes | 45,XY,−5, der(17)t inv(5;17)(p11q14;p11) [15] /46,XY [2] |
| 6 | M/82 | Yes | RAEB-T | Yes | 45,XY,−5, der(17)t(5;17)(p11;p11) [9] /46,idem,+8 [3] /45,XY,−5,add(16)(q21),−17,der(18)t(17;18)(q11;q23),+mar [1] |
| 7* | F/67 | Yes | RAEB | Yes | 44,XX,−5,−7, der(17)t(5;17)(p11;p11) [11] |
| 8 | M/57 | No | RAEB | No | 43-44,XY,add(2)(p11),−5,add(5)(p1?),der(5)t(5;17)(q13;q11),−7,−13,−17, del(20)(q12),−21,+(0-1)r,+mar1,+mar2 [7] |
| 9 | M/69 | No | RAEB | No | 44-46,XY, der(5)t(5;17)(q11;q11),del(7)(q21q34),+i(8)(q10), dup(13)(q11p13), ?add(16)(q11),−17,−(0-1)18,−21,+r [15] /46,XY [1] |
| Rearrangement between 17p and another chromosome | |||||
| 10 | M/62 | Yes | M5AML | Not evaluable | 44-46,XY,(0-1)add(2)(q35),der(7)t(1;7)(p11;p21),+(0-1)i(8)(q10), t(9;11)(p21;q23),−12,−(0-1)13,der(17)t(12;17)(q11;p11), (0-1)add(22)(p11),+(0-1)mar,(1-2)dmin(cp7) [16] |
| 11* | M/76 | No | RAEB-T | Yes | 43-45,XY,3,add(5)(p?),del(5)(q14q32),+11,add(11)(q23), der(12)t(12;17)(p12;q11),del(13)(q13q14),−17,−22,+mar,ace [cp4] |
| 12 | F/81 | No | M2AML | Yes | 41-42,XX,del(4)(q13),−5,der(9)t(9;10)(p21;q11),−12,t(13;15)(p10;p10), −15,add(16)(q11),der(17)t(17;21)(p11;q11),?i(21)(q10),−21,−22,add(22)(p11), +(1-3)mar [18] /46,XX [1] |
| 13 | F/75 | Yes | M2AML | Yes | 44-45,XX,del(5)(q11q34),−17, add(17)(p13), −18,t(?21;22)(q22;q11), mar(15),+mar1 [8] |
| 14 | F/71 | No | RAEB | Yes | 46-49,XX,del(5)(q13q33),−7,del(9)(q23q32), add(17)(p11), −18, (0-1)del(20)(q11),−21,+22,+(2-4)mar [11] /46,XX,del(5)(q13;q33) [1] /46,XX [2] |
| 15 | M/47 | Yes | RAEB | Yes | 44-45,XY,−(0-1)7,add(12)(p12),−(0-1)15, add(17)(p11), add(21)(q13), +(0-1)mar [22] |
| Monosomy 17 and i(17q) | |||||
| 16 | M/55 | Yes | M2AML | Yes | 45,XY,del(5)(q13,q33),del(11)(p12),add(15)(q23),−16,−17,−20, +mar1,+mar( cp7) [13] |
| 17 | M/68 | No | RAEB | Yes | 46,XY,i(17)(q10) [14] /46,XY [3] |
*Patients no. 2, 7, 11 had been reported in reference no. 7 as patients no. 7, 1 and 29, respectively.
Combining pseudo Pelger Huët hypolobulation and vacuoles in >5% neutrophils.