Dose-Response Relationship of Crotalin on the Elapsed Time of Inducing Thrombus Formation on Light Irradiation of Venules of Mice Pretreated With Fluorescein Sodium (150 μg per mouse)
Dose of Crotalin (μg/kg) . | Occlusion Time (s) . | |
---|---|---|
Saline . | Crotalin . | |
100 | 94 ± 7 (4) | 161 ± 28 (4)* |
200 | 97 ± 20 (4) | 273 ± 15 (4)† |
300 | 99 ± 19 (4) | 317 ± 31 (5)† |
Dose of Crotalin (μg/kg) . | Occlusion Time (s) . | |
---|---|---|
Saline . | Crotalin . | |
100 | 94 ± 7 (4) | 161 ± 28 (4)* |
200 | 97 ± 20 (4) | 273 ± 15 (4)† |
300 | 99 ± 19 (4) | 317 ± 31 (5)† |
The occlusion time was expressed (in seconds) as the time lapse for inducing platelet-rich thrombus formation on the irradiation of the venules in fluorescein sodium-treated mice. The significant difference of elapsed time was compared between groups before and after administration of crotalin. Values are presented as mean ± SEM (n).
P < .05.
P < .001.