Table 3.

Pertinent Clinical Data on the Outcome Following Allogeneic Nonmyeloablative Stem Cell Transplantation, Including Evidence for Engraftment, Acute and Chronic GVHD, Mixed Chimerism, and Outcome in Response to Allogeneic Cell-Mediated Immunotherapy

UPN ANC <100*PLT <20,000ANC >500PLT >20,0002-153Acute GVHD Mixed ChimerismChronic GVHD Relapse or Residual DiseaseOutcome
Grade On CSA2-155Off CSA¶
1031 −  4  +15  22  1  +   +   A & W2-160 
1052  −  −  +14 −  2   +   +   A & W  
1053 +11  −  +19  −  1   +  +   A & W  
1057  +8  +9  +11  +12   +  +  +   A & W  
1073  +6  +8  +15 +12  2  +    +  +  Relapse (allotCT)2-164 
1077  +10  +10  +15  +13       A & W  
1080  +  11  +18 −  0      +  A & W (alloCT)2-161 
1088  +5  +5  +10  +12       A & W  
1093  +10  +7  +14  +10 4   +     Died of GVHD  
1098  +5  +6 +11  +11  0    +  +  +  A & W (alloCT)2-162 
1099  +6  +6  +15  +12       A & W  
1109#  +2  0  +28 +36  3  +    +   A & W  
1111 −  −  +15  −       A & W  
1114  0  +0  +15  +22 0    +    A & W  
1119  −  +5 −  +22  4   +  +  +   A & W 
1123  +8  +5  +13  +15  2  +     A & W  
1124  +11  +9  +32  +35  4   +    Died of GVHD  
1131  −  +3 −  +8  4   +  +    Died of GVHD 
1133  +9  +4  +18  +12  0       A & W  
1135  −  +8  +18  +10  4      Died of GVHD  
1137  −  +9  +12 +13  0    +   +  A & W (alloCT)2-166 
1140  −  +8  +9 +17  0       A & W  
1141  +7  +7 −14  +15  0       A & W  
1143  +10 +7  +18  +11  0       A & W  
1156 +4  0  +13  +13  0       A & W 
1158  +6  +8  +10  0  0       A & W 
UPN ANC <100*PLT <20,000ANC >500PLT >20,0002-153Acute GVHD Mixed ChimerismChronic GVHD Relapse or Residual DiseaseOutcome
Grade On CSA2-155Off CSA¶
1031 −  4  +15  22  1  +   +   A & W2-160 
1052  −  −  +14 −  2   +   +   A & W  
1053 +11  −  +19  −  1   +  +   A & W  
1057  +8  +9  +11  +12   +  +  +   A & W  
1073  +6  +8  +15 +12  2  +    +  +  Relapse (allotCT)2-164 
1077  +10  +10  +15  +13       A & W  
1080  +  11  +18 −  0      +  A & W (alloCT)2-161 
1088  +5  +5  +10  +12       A & W  
1093  +10  +7  +14  +10 4   +     Died of GVHD  
1098  +5  +6 +11  +11  0    +  +  +  A & W (alloCT)2-162 
1099  +6  +6  +15  +12       A & W  
1109#  +2  0  +28 +36  3  +    +   A & W  
1111 −  −  +15  −       A & W  
1114  0  +0  +15  +22 0    +    A & W  
1119  −  +5 −  +22  4   +  +  +   A & W 
1123  +8  +5  +13  +15  2  +     A & W  
1124  +11  +9  +32  +35  4   +    Died of GVHD  
1131  −  +3 −  +8  4   +  +    Died of GVHD 
1133  +9  +4  +18  +12  0       A & W  
1135  −  +8  +18  +10  4      Died of GVHD  
1137  −  +9  +12 +13  0    +   +  A & W (alloCT)2-166 
1140  −  +8  +9 +17  0       A & W  
1141  +7  +7 −14  +15  0       A & W  
1143  +10 +7  +18  +11  0       A & W  
1156 +4  0  +13  +13  0       A & W 
1158  +6  +8  +10  0  0       A & W 

*First day when ANC dropped below 0.1 × 109/L.

First day when platelets dropped below 20 × 109/L.

First day when ANC rose above 0.5 × 109/L.

F2-153

First day platelet count rose above 20 × 109/L; transfusion independent.

F2-155

GVHD initiated when patient was on CSA therapy.

¶GVHD initiated when patient was off CSA therapy.

#Donor was a single locus A and C mismatched sibling, with a positive one way host anti-donor mixed lymphocyte culture.

F2-160

Alive and well, including patients with chronic GVHD, which was not extensive in any of the patients.

F2-164

Patient with hematologic relapse 8 months following allogeneic nonmyeloablative stem cell transplantation currently under remission induction with a combination of chemotherapy for tumor debulking and allogeneic cell therapy (alloCT), in parallel with development of grade 2 GVHD.

F2-161

Patient with overt hematologic relapse at 4 months following allogeneic nonmyeloblative stem cell transplantation successfully treated by a combination of chemotherapy for tumor debulking and allogeneic cell therapy T, in parallel with development of grade 2 GVHD, with no evidence of diseases, with 100% donor-type (female) cells by cytogenetic analysis and no male cells by PCR.

F2-162

Male patient with tumor cells completely resistant to all chemotherapy at the time of admission, with residual disease following allogeneic non-myeloablative stem cell transplantation with marrow infiltration with lymphoma cells, successfully treated with allogeneic cell therapy in parallel with development of grade 2 GVHD, currently with no evidence of diseases, with 100% donor-type (female) cells by cytogenetic analysis and no male cells by PCR.

F2-166

Patient with no hematologic evidence of disease treated with allogeneic cell therapy for cytogenetic relapse with positive bcr-abl RT-PCR.

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