Regulation of Hemostasis and Thrombosis by the Endothelium
| . | Antithrombotic . | Prothrombotic . |
|---|---|---|
| Coagulation protein binding sites | Glycosaminoglycans/ATIII | Binding sites for: fibrin, FIX, IXa, X, Xa, FXII, kallikrein |
| TFPI | Tissue factor | |
| Thrombomodulin | Thrombin receptor | |
| Receptor for protein C/APC | ||
| Products produced and/or stored by platelets | PGI2 NO ADPase | vWF PAF Fibrinogen FV FXI |
| Fibrinolytic factors | t-PA production u-PA expression | PAI-1, PAI-2 PAI-3 (protein C Inhibitor) |
| u-PAR | TAFI activation | |
| Plasminogen binding sites | ||
| Annexin II | ||
| Vasomotor factors | NO PGI2 | TxA2 Endothelin-1 |
| . | Antithrombotic . | Prothrombotic . |
|---|---|---|
| Coagulation protein binding sites | Glycosaminoglycans/ATIII | Binding sites for: fibrin, FIX, IXa, X, Xa, FXII, kallikrein |
| TFPI | Tissue factor | |
| Thrombomodulin | Thrombin receptor | |
| Receptor for protein C/APC | ||
| Products produced and/or stored by platelets | PGI2 NO ADPase | vWF PAF Fibrinogen FV FXI |
| Fibrinolytic factors | t-PA production u-PA expression | PAI-1, PAI-2 PAI-3 (protein C Inhibitor) |
| u-PAR | TAFI activation | |
| Plasminogen binding sites | ||
| Annexin II | ||
| Vasomotor factors | NO PGI2 | TxA2 Endothelin-1 |
Outline of the antithrombotic and prothrombotic properties of ECs detailing the binding sites expressed by ECs, the factors stored and/or secreted by ECs that affect platelet function, factors produced by the EC that influence the fibrinolytic state of the vasculature, and vasomotor substances secreted by the EC.
Abbreviations: ATIII, antithrombin III; PGI2, prostacyclin; TFPI, tissue factor pathway inhibitor; APC, activated protein C; PAF, platelet-activating factor; t-PA, tissue plasminogen activator; u-PA, urokinase plasminogen activator; u-PAR, urokinase plasminogen activator receptor; PAI, plasminogen activator inhibitor; TAFI, thrombin activatable fibrinolysis inhibitor; TxA2, thromboxane A2.