Table 2. Cytotoxicity of RFB4(dsFv)PE38... | American Society of Hematology

Table 2.

Cytotoxicity of RFB4(dsFv)PE38 Toward Various Cell Lines

Cell line^*	Source	IC₅₀ (ng/mL)† of RFB4(dsFv)PE38
CA46	Burkitt's lymphoma	0.6
Daudi		20
JD-38		0.3
Namalwa		1.5
Raji		0.4
HUT102	T-cell leukemia	>1,000

Cell line^*	Source	IC₅₀ (ng/mL)† of RFB4(dsFv)PE38
CA46	Burkitt's lymphoma	0.6
Daudi		20
JD-38		0.3
Namalwa		1.5
Raji		0.4
HUT102	T-cell leukemia	>1,000

All the cell lines are of human origin.

†

Cytotoxicity data are given as IC₅₀s , which are the concentrations of immunotoxin that cause a 50% reduction in protein synthesis compared with controls after incubation with cells for 24 hours.

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