Table 1.

Peripheral Blood Counts

Age (wk)Peripheral Blood ParameterGenotype
Wild-TypeIL-6 (−/−)G-CSFR (−/−)IL-6 × GR (−/−)
4-5 WBC (×10−9/L) 6.51 ± 1.42 6.06 ± 2.28 6.86 ± 2.45 7.03 ± 2.07 
 RBC (×10−12/L) 7.76 ± 0.64 7.98 ± 0.74 8.45 ± 1.24 7.33 ± 1.06 
 Platelet (×10−12/L) 0.85 ± 0.28 0.77 ± 0.16 0.98 ± 0.19 0.96 ± 0.25 
 PMN (%) 10.05 ± 3.03 12.60 ± 3.30 2.53 ± 1.27* 0.84 ± 0.34*† 
 PMN (×10−9/L) 0.64 ± 0.17 0.73 ± 0.26 0.17 ± 0.09* 0.06 ± 0.03*† 
 Eosinophil (×10−9/L) 0.17 ± 0.10 0.10 ± 0.06 0.08 ± 0.09 0.09 ± 0.06 
 Lymph (×10−9/L) 5.37 ± 1.35 5.00 ± 1.98 6.30 ± 2.32 6.65 ± 1.99 
15 WBC (×10−9/L) 11.14 ± 2.84 8.32 ± 2.06 8.67 ± 3.24 7.00 ± 3.54 
 RBC (×10−12/L) 9.39 ± 0.56 9.15 ± 0.50 10.11 ± 0.77 9.53 ± 0.90 
 Platelet (×10−12/L) 1.36 ± 0.20 1.21 ± 0.12 1.22 ± 0.25 1.05 ± 0.28 
 PMN (%) 13.71 ± 4.66 13.89 ± 3.99 2.62 ± 1.06* 2.07 ± 0.89* 
 PMN (×10−9/L) 1.48 ± 0.58 1.19 ± 0.59 0.23 ± 0.14* 0.14 ± 0.09* 
 Eosinophil (×10−9/L) 0.26 ± 0.22 0.19 ± 0.10 0.15 ± 0.09 0.14 ± 0.08 
 Lymph (×10−9/L) 8.72 ± 2.26 6.58 ± 1.47 7.79 ± 2.86 6.34 ± 3.32 
Age (wk)Peripheral Blood ParameterGenotype
Wild-TypeIL-6 (−/−)G-CSFR (−/−)IL-6 × GR (−/−)
4-5 WBC (×10−9/L) 6.51 ± 1.42 6.06 ± 2.28 6.86 ± 2.45 7.03 ± 2.07 
 RBC (×10−12/L) 7.76 ± 0.64 7.98 ± 0.74 8.45 ± 1.24 7.33 ± 1.06 
 Platelet (×10−12/L) 0.85 ± 0.28 0.77 ± 0.16 0.98 ± 0.19 0.96 ± 0.25 
 PMN (%) 10.05 ± 3.03 12.60 ± 3.30 2.53 ± 1.27* 0.84 ± 0.34*† 
 PMN (×10−9/L) 0.64 ± 0.17 0.73 ± 0.26 0.17 ± 0.09* 0.06 ± 0.03*† 
 Eosinophil (×10−9/L) 0.17 ± 0.10 0.10 ± 0.06 0.08 ± 0.09 0.09 ± 0.06 
 Lymph (×10−9/L) 5.37 ± 1.35 5.00 ± 1.98 6.30 ± 2.32 6.65 ± 1.99 
15 WBC (×10−9/L) 11.14 ± 2.84 8.32 ± 2.06 8.67 ± 3.24 7.00 ± 3.54 
 RBC (×10−12/L) 9.39 ± 0.56 9.15 ± 0.50 10.11 ± 0.77 9.53 ± 0.90 
 Platelet (×10−12/L) 1.36 ± 0.20 1.21 ± 0.12 1.22 ± 0.25 1.05 ± 0.28 
 PMN (%) 13.71 ± 4.66 13.89 ± 3.99 2.62 ± 1.06* 2.07 ± 0.89* 
 PMN (×10−9/L) 1.48 ± 0.58 1.19 ± 0.59 0.23 ± 0.14* 0.14 ± 0.09* 
 Eosinophil (×10−9/L) 0.26 ± 0.22 0.19 ± 0.10 0.15 ± 0.09 0.14 ± 0.08 
 Lymph (×10−9/L) 8.72 ± 2.26 6.58 ± 1.47 7.79 ± 2.86 6.34 ± 3.32 

Manual 300-count leukocyte differentials were performed on blood smears from sex-matched mice. A total of 8 and 6 mice of each genotype were analyzed at 4 to 5 and 15 weeks, respectively. Data represent the mean ± SD.

*

P < .001 compared with wild-type mice.

†

P < 0.01 compared with G-CSFR (−/−) mice.

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