Table 4. Effect of Blocking Egr-1... | American Society of Hematology

Table 4.

Effect of Blocking Egr-1 Expression on GM-CSF–Induced Differentiation of 32DHOX-B8 Cells

Clone	Oligos^4-150	Cell Type (%)^4-151
		Blast	Granulocytes	Macrophage
			Inter	Inter	Mat
32Dneo	None	88	12	0	0
	Scrambled	87	13	0	0
	Antisense	89	11	0	0
32DEgr1.2	None	3	0	8	89
	Scrambled	4	0	9	87
	Antisense	21	0	69	10
32DHOX-B8/6	None	4	0	28	68
	Scrambled	6	0	26	68
	Antisense	41	0	49	10
32DHOX-B8/18	None	5	0	31	64
	Scrambled	7	0	30	62
	Antisense	36	0	50	14

Clone	Oligos^4-150	Cell Type (%)^4-151
		Blast	Granulocytes	Macrophage
			Inter	Inter	Mat
32Dneo	None	88	12	0	0
	Scrambled	87	13	0	0
	Antisense	89	11	0	0
32DEgr1.2	None	3	0	8	89
	Scrambled	4	0	9	87
	Antisense	21	0	69	10
32DHOX-B8/6	None	4	0	28	68
	Scrambled	6	0	26	68
	Antisense	41	0	49	10
32DHOX-B8/18	None	5	0	31	64
	Scrambled	7	0	30	62
	Antisense	36	0	50	14

F4-150

Cells were treated with oligomers as described in Materials and Methods.

F4-151

Cell morphology was determined after 10 days treatment with indicated oligomers and GM-CSF (10 ng/mL). All values represent the mean of at least three independent experiments, as indicated in Materials and Methods.

View Large

This Feature Is Available To Subscribers Only