Effect of Chloroquine on Antigen Processing and Presentation by CD38++ Plasma Cells
| Experiments . | Chloroquine . | No Antigen . | PPD . | Inhibition (%) . |
|---|---|---|---|---|
| Presence in cultures | − | 320 ± 110 | 2,320 ± 430 | |
| + | 298 ± 122 | 302 ± 116 | 100 | |
| During pulse of plasma cells with PPD | − | 240 ± 88 | 1,504 ± 340 | |
| + | 280 ± 110 | 380 ± 122 | 92 | |
| Pretreatment of plasma cells | − | 250 ± 98 | 1,882 ± 240 | |
| + | 220 ± 112 | 579 ± 125 | 78 |
| Experiments . | Chloroquine . | No Antigen . | PPD . | Inhibition (%) . |
|---|---|---|---|---|
| Presence in cultures | − | 320 ± 110 | 2,320 ± 430 | |
| + | 298 ± 122 | 302 ± 116 | 100 | |
| During pulse of plasma cells with PPD | − | 240 ± 88 | 1,504 ± 340 | |
| + | 280 ± 110 | 380 ± 122 | 92 | |
| Pretreatment of plasma cells | − | 250 ± 98 | 1,882 ± 240 | |
| + | 220 ± 112 | 579 ± 125 | 78 |
PPD-induced T-cell proliferation was measured on day 6. Means ± SD were determined on triplicate values of two experiments.