The Relation Between In Vitro Drug Resistance and Probability of DFS (pDFS) 3 Years From Diagnosis, in 152 Children With Newly Diagnosed ALL
| Drug . | 3-yr pDFS (%) With SE in Parentheses . | P Value3-150 . | ||
|---|---|---|---|---|
| . | Sensitive . | Intermediate . | Resistant . | . |
| Prednisolone | 100 | 78 (5) | 42 (10) | <.001 |
| Dexamethasone | 88 (5) | 70 (8) | 60 (9) | .012 |
| L-asparaginase | 95 (4) | 68 (8) | 52 (10) | <.001 |
| Vincristine | 91 (5) | 63 (8) | 66 (8) | .003 |
| Vindesine | 82 (7) | 67 (9) | 72 (8) | .096 |
| Daunorubicin | 79 (7) | 74 (8) | 64 (9) | .66 |
| Doxorubicin | 79 (8) | 79 (9) | 61 (9) | .052 |
| Mitoxantrone | 77 (8) | 78 (8) | 63 (9) | .12 |
| Mercaptopurine | 81 (7) | 78 (8) | 63 (9) | .17 |
| Thioguanine | 84 (7) | 71 (8) | 68 (8) | .58 |
| Cytarabine | 72 (8) | 82 (7) | 63 (9) | .32 |
| Teniposide | 79 (8) | 72 (9) | 69 (9) | .48 |
| Resistance profile3-151 | 100 | 84 (6) | 43 (8) | <.001 |
| Drug . | 3-yr pDFS (%) With SE in Parentheses . | P Value3-150 . | ||
|---|---|---|---|---|
| . | Sensitive . | Intermediate . | Resistant . | . |
| Prednisolone | 100 | 78 (5) | 42 (10) | <.001 |
| Dexamethasone | 88 (5) | 70 (8) | 60 (9) | .012 |
| L-asparaginase | 95 (4) | 68 (8) | 52 (10) | <.001 |
| Vincristine | 91 (5) | 63 (8) | 66 (8) | .003 |
| Vindesine | 82 (7) | 67 (9) | 72 (8) | .096 |
| Daunorubicin | 79 (7) | 74 (8) | 64 (9) | .66 |
| Doxorubicin | 79 (8) | 79 (9) | 61 (9) | .052 |
| Mitoxantrone | 77 (8) | 78 (8) | 63 (9) | .12 |
| Mercaptopurine | 81 (7) | 78 (8) | 63 (9) | .17 |
| Thioguanine | 84 (7) | 71 (8) | 68 (8) | .58 |
| Cytarabine | 72 (8) | 82 (7) | 63 (9) | .32 |
| Teniposide | 79 (8) | 72 (9) | 69 (9) | .48 |
| Resistance profile3-151 | 100 | 84 (6) | 43 (8) | <.001 |