“Established” indications are those in which desmopressin normalizes the bleeding time and factor VIII levels, and is clinically efficacious; “Possible” indications, those in which the effect on the bleeding time is absent or inconsistent, with little data on clinical efficacy; “Doubtful” indications, those in which desmopressin does not normalize factor VIII levels or the bleeding time, and is not clinically efficacious.