Recommended Dosages of Desmopressin and Factor VIII With vWF Responses in Patients With Hemophilia and vWD
| Single dose | Intravenous and subcutaneous: 0.3 μg/kg |
| Intranasal: 300 μg/kg | |
| Mean factor increase over baseline | 3-5 times |
| (range: 1.5-20 times) | |
| Time to peak levels | 30-60 min after intravenous injection |
| 90-120 min after subcutaneous injection and intranasal application | |
| Plasma half-life | 5-8 hours for factor VIII |
| 8-10 hours for vWF |
| Single dose | Intravenous and subcutaneous: 0.3 μg/kg |
| Intranasal: 300 μg/kg | |
| Mean factor increase over baseline | 3-5 times |
| (range: 1.5-20 times) | |
| Time to peak levels | 30-60 min after intravenous injection |
| 90-120 min after subcutaneous injection and intranasal application | |
| Plasma half-life | 5-8 hours for factor VIII |
| 8-10 hours for vWF |