Diseases of Genomic Instability
| Disease . | Damaging Agent . | Neoplasm . | Function . |
|---|---|---|---|
| FA | Cross-linking agents | Acute myeloblastic leukemia, hepatic, gastrointestinal, and gynecological tumors | Unknown |
| XP | UV light | Squamous cell carcinomas | Excision repair |
| AT | Ionizing radiation | Lymphoma | Afferent pathway to p53 |
| Bloom's syndrome | Alkylating agents | Acute lymphoblastic leukemia | Cell-cycle regulation |
| Cockayne's syndrome | UV light | Basal cell carcinoma | Transcription coupled repair |
| Hereditary nonpolyposis colon cancer (HNPCC) | Unknown | Adenocarcinoma of colon, ovarian cancer | DNA mismatch repair |
| Disease . | Damaging Agent . | Neoplasm . | Function . |
|---|---|---|---|
| FA | Cross-linking agents | Acute myeloblastic leukemia, hepatic, gastrointestinal, and gynecological tumors | Unknown |
| XP | UV light | Squamous cell carcinomas | Excision repair |
| AT | Ionizing radiation | Lymphoma | Afferent pathway to p53 |
| Bloom's syndrome | Alkylating agents | Acute lymphoblastic leukemia | Cell-cycle regulation |
| Cockayne's syndrome | UV light | Basal cell carcinoma | Transcription coupled repair |
| Hereditary nonpolyposis colon cancer (HNPCC) | Unknown | Adenocarcinoma of colon, ovarian cancer | DNA mismatch repair |