Effect of Anti-HM1.24 MoAb on the Prevention of Human ARH-77 Myeloma Engraftment
| Tumor Inoculation . | Treatment (day) . | Tumor/Total Mice . | Serum Human IgG (μg/mL) . | Survival (days) . |
|---|---|---|---|---|
| IV | Control IgG (1, 15) | 5/5 | 273 ± 174 | 53 ± 21 |
| Anti-HM1.24 IgG (1) | 0/5 | 0 ± 0 | >180† | |
| Anti-HM1.24 IgG (15) | 5/5 | 60 ± 73* | 48 ± 12 | |
| SC | Control IgG (1, 15) | 5/5 | 373 ± 117 | 67 ± 19 |
| Anti-HM1.24 IgG (1) | 5/5 | 269 ± 160 | 61 ± 6 | |
| Anti-HM1.24 IgG (15) | 5/5 | 321 ± 180 | 65 ± 16 |
| Tumor Inoculation . | Treatment (day) . | Tumor/Total Mice . | Serum Human IgG (μg/mL) . | Survival (days) . |
|---|---|---|---|---|
| IV | Control IgG (1, 15) | 5/5 | 273 ± 174 | 53 ± 21 |
| Anti-HM1.24 IgG (1) | 0/5 | 0 ± 0 | >180† | |
| Anti-HM1.24 IgG (15) | 5/5 | 60 ± 73* | 48 ± 12 | |
| SC | Control IgG (1, 15) | 5/5 | 373 ± 117 | 67 ± 19 |
| Anti-HM1.24 IgG (1) | 5/5 | 269 ± 160 | 61 ± 6 | |
| Anti-HM1.24 IgG (15) | 5/5 | 321 ± 180 | 65 ± 16 |
SCID mice were treated with a single intraperitoneal injection of antibody (20 μg/day) after inoculation of ARH-77 cells. The concentrations of serum human IgG were measured at day 28 after tumor inoculation. Data represent the mean ± SD of serum human IgG or survival. P values are based on the comparison between the indicated experimental and the control IgG-treated groups.
Abbreviations: IV, intravenously; SC, subcutaneously.
P < .05.
P < .005.