Table 5. Analyses of EFS From Start of... | American Society of Hematology

Table 5.

Analyses of EFS From Start of Treatment

Variable	Median EFS^5-150 (95% CI)	Univariate P Value^5-151	Multivariate P Value	Comment

inv16 or t(8; 21)	None [65, −]	.003	.029	Unfavorable effect complex −5, −7 increases with time
Complex −5, −7	10 [8, 15]	<.001	<.001
Other abnormal or IM	24 [17, 32]	<.001	.002
Normal karyotype	46 [30, 76]	<.001	—
PS ≤ 2	31 [27, 37]	<.001	<.001	Unfavorable effect PS > 2 levels off by 12 weeks
PS > 2	4 [2, 10]		—
LAFR	31 [27, 41]	<.001	.003	LAFR favorable only for initial 8 weeks
No LAFR	17 [11, 24]		—
IA	52 [37, 81]	.003	—	Unfavorable effect F + A disappears by 32 weeks
IA + G	57 [33, 76]	<.001	NS
F + A	12 [10, 28]	.015	.05
FLAG	23 [15, 31]	.24	NS
FLAG + Ida	14.5 [12, 21]	<.001	NS
RAEB	18 [13, 26]	.047	NS
RAEB-t	30 [21, 46]	.59	NS (.081)
AML	29 [22, 35]	.48	—
Age	Decreases with increasing age	<.001	.001	Unfavorable effect increasing age disappears by 40 wk from start of treatment
AHD	Decreases with length of AHD up to plateau at AHD of 10-20 mo	<.001	<.001

Variable	Median EFS^5-150 (95% CI)	Univariate P Value^5-151	Multivariate P Value	Comment

inv16 or t(8; 21)	None [65, −]	.003	.029	Unfavorable effect complex −5, −7 increases with time
Complex −5, −7	10 [8, 15]	<.001	<.001
Other abnormal or IM	24 [17, 32]	<.001	.002
Normal karyotype	46 [30, 76]	<.001	—
PS ≤ 2	31 [27, 37]	<.001	<.001	Unfavorable effect PS > 2 levels off by 12 weeks
PS > 2	4 [2, 10]		—
LAFR	31 [27, 41]	<.001	.003	LAFR favorable only for initial 8 weeks
No LAFR	17 [11, 24]		—
IA	52 [37, 81]	.003	—	Unfavorable effect F + A disappears by 32 weeks
IA + G	57 [33, 76]	<.001	NS
F + A	12 [10, 28]	.015	.05
FLAG	23 [15, 31]	.24	NS
FLAG + Ida	14.5 [12, 21]	<.001	NS
RAEB	18 [13, 26]	.047	NS
RAEB-t	30 [21, 46]	.59	NS (.081)
AML	29 [22, 35]	.48	—
Age	Decreases with increasing age	<.001	.001	Unfavorable effect increasing age disappears by 40 wk from start of treatment
AHD	Decreases with length of AHD up to plateau at AHD of 10-20 mo	<.001	<.001

Abbreviation: NS, not significant.

EFS measured in weeks.

Log-rank test.