Comparison of Binding Affinities of ATRA and Synthetic Retinoids
| . | RAR . | RXR . | CRABP . | ||||
|---|---|---|---|---|---|---|---|
| . | α . | β . | γ . | α . | β . | γ . | . |
| Agonist | |||||||
| ATRA | + | + | + | − | − | − | + |
| Am80 | + | + | − | − | − | − | ± |
| Ch55 | ++ | ++ | ++ | − | − | − | − |
| Ro25-7386 | − | − | − | + | − | + | |
| Antagonist | |||||||
| LE540 | ± | + | − | ||||
| Ro41-5253 | + | − | − | ||||
| . | RAR . | RXR . | CRABP . | ||||
|---|---|---|---|---|---|---|---|
| . | α . | β . | γ . | α . | β . | γ . | . |
| Agonist | |||||||
| ATRA | + | + | + | − | − | − | + |
| Am80 | + | + | − | − | − | − | ± |
| Ch55 | ++ | ++ | ++ | − | − | − | − |
| Ro25-7386 | − | − | − | + | − | + | |
| Antagonist | |||||||
| LE540 | ± | + | − | ||||
| Ro41-5253 | + | − | − | ||||
Comparisons of the binding affinities of retinoids used in this study for RARs, RXRs, and CRABP are briefly summarized according to previous reports6-9 and data from F. Hoffman-La Roche, Ltd.