The Synergistic and Additive Effects of IL-15 and IL-12 on Cord Blood NK Cytotoxicity Against K562
| IL-12 (U/mL) . | IL-15 (ng/mL) . | |||||
|---|---|---|---|---|---|---|
| . | 0 . | 0.1 . | 0.5 . | 1.0 . | 5.0 . | 10 . |
| 0 | 54 ± 10* | 133 ± 19 | 179 ± 29 | 383 ± 61 | 473 ± 70 | |
| 0.1 | 156 ± 23 | 227 ± 28 (+8%)† | 383 ± 63 (+33%) | 405 ± 59 (+21%) | 534 ± 92 (−1%) | 307 ± 71 (−51%) |
| 0.5 | 283 ± 32 | 368 ± 63 (+9%) | 486 ± 65 (+17%) | 532 ± 64 (+15%) | ND | ND |
| 1.0 | 352 ± 54 | 449 ± 64 (+10%) | 554 ± 65 (+14%) | 489 ± 71 (−8%) | 514 ± 107 (−30%) | 495 ± 97 (−40%) |
| 10 | 410 ± 48 | 509 ± 67 (+9%) | ND | 559 ± 65 (−5%) | 457 + 92 (−42%) | 631 ± 91 (−29%) |
| IL-12 (U/mL) . | IL-15 (ng/mL) . | |||||
|---|---|---|---|---|---|---|
| . | 0 . | 0.1 . | 0.5 . | 1.0 . | 5.0 . | 10 . |
| 0 | 54 ± 10* | 133 ± 19 | 179 ± 29 | 383 ± 61 | 473 ± 70 | |
| 0.1 | 156 ± 23 | 227 ± 28 (+8%)† | 383 ± 63 (+33%) | 405 ± 59 (+21%) | 534 ± 92 (−1%) | 307 ± 71 (−51%) |
| 0.5 | 283 ± 32 | 368 ± 63 (+9%) | 486 ± 65 (+17%) | 532 ± 64 (+15%) | ND | ND |
| 1.0 | 352 ± 54 | 449 ± 64 (+10%) | 554 ± 65 (+14%) | 489 ± 71 (−8%) | 514 ± 107 (−30%) | 495 ± 97 (−40%) |
| 10 | 410 ± 48 | 509 ± 67 (+9%) | ND | 559 ± 65 (−5%) | 457 + 92 (−42%) | 631 ± 91 (−29%) |
Abbreviation: ND, not done.
NK cytotoxicity (lytic units) in Table 1 is presented as the mean ± SEM (n = 8).