Coagulation and FVII Antigen Indices of the FVII (N57D) Kindred
Subject . | Exon 4 Genotype . | Laboratory 1* . | Laboratory 2* . | ||
---|---|---|---|---|---|
FVII:Ag (%) . | FVII:C (U/mL) . | FVII:Ag (%) . | FVII:C (U/mL) . | ||
II1 | H | 96 | 0.75 | 97 | 0.71 |
III2 | H | 102 | 0.67 | 92 | 0.66 |
III3† | H | 51 | 0.32 | 72 | 0.37 |
IV3 | H | 86 | 0.57 | 80 | 0.60 |
Mean‡ | 84 | 0.58 | 85 | 0.59 |
Subject . | Exon 4 Genotype . | Laboratory 1* . | Laboratory 2* . | ||
---|---|---|---|---|---|
FVII:Ag (%) . | FVII:C (U/mL) . | FVII:Ag (%) . | FVII:C (U/mL) . | ||
II1 | H | 96 | 0.75 | 97 | 0.71 |
III2 | H | 102 | 0.67 | 92 | 0.66 |
III3† | H | 51 | 0.32 | 72 | 0.37 |
IV3 | H | 86 | 0.57 | 80 | 0.60 |
Mean‡ | 84 | 0.58 | 85 | 0.59 |
Abbreviation: H, heterozygous.
Experiments were performed on both identical fresh plasma samples and a single lot of normal pooled plasma by two independent laboratories. All values are compared to normal pooled plasma which was assigned values of 100% FVII:Ag and 1 unit/ml FVII:C activity.
Propositus.
The mean of FVII antigen and coagulant activities from affected family members.