Manifestations of Amyloidosis
| Genotype . | Incidence of . | No. of Affected . | Percentage of Organs Positive in Affected Animals (mean severity score*) . | |||||
|---|---|---|---|---|---|---|---|---|
| . | Amyloid (%) . | Mice Examined . | Liver . | Spleen . | Kidney . | Bowel . | Heart . | Lung . |
| Wild-type | 4 | 1 | 0 (0) | 0 (0) | 100 (1.0) | 0 (0) | 0 (0) | 100 (1.0) |
| GM−/− | 10 | 4 | 100 (1.5) | 100 (1.3) | 50 (0.5) | 50 (0.8) | 75 (0.8) | 50 (0.5) |
| G−/− | 46 | 22 | 86 (1.3) | 86 (1.8) | 67 (1.1) | 73 (1.1) | 73 (0.8) | 36 (0.4) |
| G−/−GM−/− | 32 | 23 | 91 (1.3) | 91 (1.6) | 64 (0.7) | 71 (1.1) | 48 (0.5) | 57 (0.6) |
| Total | 27 | 50 | 88 (1.3) | 88 (1.6) | 65 (0.9) | 69 (1.0) | 60 (0.6) | 48 (0.5) |
| Genotype . | Incidence of . | No. of Affected . | Percentage of Organs Positive in Affected Animals (mean severity score*) . | |||||
|---|---|---|---|---|---|---|---|---|
| . | Amyloid (%) . | Mice Examined . | Liver . | Spleen . | Kidney . | Bowel . | Heart . | Lung . |
| Wild-type | 4 | 1 | 0 (0) | 0 (0) | 100 (1.0) | 0 (0) | 0 (0) | 100 (1.0) |
| GM−/− | 10 | 4 | 100 (1.5) | 100 (1.3) | 50 (0.5) | 50 (0.8) | 75 (0.8) | 50 (0.5) |
| G−/− | 46 | 22 | 86 (1.3) | 86 (1.8) | 67 (1.1) | 73 (1.1) | 73 (0.8) | 36 (0.4) |
| G−/−GM−/− | 32 | 23 | 91 (1.3) | 91 (1.6) | 64 (0.7) | 71 (1.1) | 48 (0.5) | 57 (0.6) |
| Total | 27 | 50 | 88 (1.3) | 88 (1.6) | 65 (0.9) | 69 (1.0) | 60 (0.6) | 48 (0.5) |
There were no statistically significant differences evident in either the distribution or severity of amyloidosis between genotypes.
Severity of amyloid deposition was scored using the criteria of Janigan,14 where 1 = slight, 2 = moderate, and 3 = extensive, as originally defined.