Criteria for the Diagnosis of JMML
| Category . | Item . |
|---|---|
| Suggestive clinical features Minimal laboratory criteria (all 3 have to be fulfilled) Criteria requested for definite diagnosis (at least 2) | 1. Hepatosplenomegaly (97%) 2. Lymphadenopathy (76%) 3. Pallor (64%) 4. Fever (54%) 5. Skin rash (36%) 1. No Ph chromosome, no bcr-abl rearrangement 2. Peripheral blood monocyte count >1 × 109/L 3. Bone marrow blasts <20% 1. Hemoglobin F increased for age 2. Myeloid precursors on peripheral blood smear 3. White blood count >10 × 109/L 4. Clonal abnormality (including monosomy 7) 5. GM-CSF hypersensitivity of myeloid progenitors in vitro |
| Category . | Item . |
|---|---|
| Suggestive clinical features Minimal laboratory criteria (all 3 have to be fulfilled) Criteria requested for definite diagnosis (at least 2) | 1. Hepatosplenomegaly (97%) 2. Lymphadenopathy (76%) 3. Pallor (64%) 4. Fever (54%) 5. Skin rash (36%) 1. No Ph chromosome, no bcr-abl rearrangement 2. Peripheral blood monocyte count >1 × 109/L 3. Bone marrow blasts <20% 1. Hemoglobin F increased for age 2. Myeloid precursors on peripheral blood smear 3. White blood count >10 × 109/L 4. Clonal abnormality (including monosomy 7) 5. GM-CSF hypersensitivity of myeloid progenitors in vitro |
Numbers in parenthesis refer to the percentage of patients with the particular clinical feature.2-1
Abbreviation: Ph, Philadelphia.