T-Lymphoproliferative Disorders
| Disorder . | Common Phenotype . | Comments/Variation . | Potentially Associated Genetic Abnormalities . |
|---|---|---|---|
| T-prolymphocyte leukemia | CD2, CD3, CD5, CD7, CD4, CD8(−) | Dual CD4/CD8 or CD4(−), CD8 rare | Alterations of 14q11 and 14q32 |
| Clonal TCR rearrangement | |||
| Large granular lymphocytic leukemia-T | CD2, CD3, CD5(−), CD7(−), CD4(−), CD8, CD16, CD11b, CD56(−), CD57, CD25(−) | CD3, CD56 variant more aggressive | Clonal TCR rearrangement |
| Large granular lymphocytic leukemia-NK | CD2, CD3(−), CD16, CD56, CD4(−), CD8−/+, CD56, CD57(−), CD25(−) | No TCR rearrangement | |
| Mycosis fungoides Sézary syndrome | CD2, CD3, CD5, CE7+/−, CD4, CD8(−), CD25(−) | May not have aberrant phenotype | Clonal TCR rearrangement |
| Adult T-cell leukemia/lymphoma | CD2, CD3, CD5, CD7(−), CD4, CD8(−), DR, bright CD25 | L-selectin overexpressed | Abnormalities of p53 with progression |
| HTLV-I | Clonal TCR rearrangement | ||
| T-chronic lymphocytic leukemia | CD2, CD3, CD5, CD7, CD4, CD8(−) | Aberrant pattern unusual CD8, CD4(−) rare | Clonal TCR rearrangement |
| Disorder . | Common Phenotype . | Comments/Variation . | Potentially Associated Genetic Abnormalities . |
|---|---|---|---|
| T-prolymphocyte leukemia | CD2, CD3, CD5, CD7, CD4, CD8(−) | Dual CD4/CD8 or CD4(−), CD8 rare | Alterations of 14q11 and 14q32 |
| Clonal TCR rearrangement | |||
| Large granular lymphocytic leukemia-T | CD2, CD3, CD5(−), CD7(−), CD4(−), CD8, CD16, CD11b, CD56(−), CD57, CD25(−) | CD3, CD56 variant more aggressive | Clonal TCR rearrangement |
| Large granular lymphocytic leukemia-NK | CD2, CD3(−), CD16, CD56, CD4(−), CD8−/+, CD56, CD57(−), CD25(−) | No TCR rearrangement | |
| Mycosis fungoides Sézary syndrome | CD2, CD3, CD5, CE7+/−, CD4, CD8(−), CD25(−) | May not have aberrant phenotype | Clonal TCR rearrangement |
| Adult T-cell leukemia/lymphoma | CD2, CD3, CD5, CD7(−), CD4, CD8(−), DR, bright CD25 | L-selectin overexpressed | Abnormalities of p53 with progression |
| HTLV-I | Clonal TCR rearrangement | ||
| T-chronic lymphocytic leukemia | CD2, CD3, CD5, CD7, CD4, CD8(−) | Aberrant pattern unusual CD8, CD4(−) rare | Clonal TCR rearrangement |
Abbreviations: +/−, variable, more often positive; −/+, variable, more often negative; (−), negative; TCR, T-cell receptor.