B-Lymphoproliferative Disorders
| Disorder . | Common Phenotype . | Comments/Variations . | Potentially Associated Genetic Abnormalities . |
|---|---|---|---|
| Chronic lymphocytic leukemia/small cell lymphocytic lymphoma | DR, CD19, CD20, CD5, CD22(−), CD23, CD10(−), CD11c+/−, CD25+/−, CD43, clonal SIgM and SIgD weak | CD20 dim | Abnormalities of 13q, 14q, 11q |
| BCL-2 overexpressed | |||
| Bright SIg, CD20, FMC7 | |||
| Trisomy 12 | |||
| Prolymphocytic leukemia | DR, CD19, CD20, CD5(−), CD22, CD23(−), CD10(−), bright clonal SIg | CD20 bright | No consistent alteration |
| Mantle cell lymphoma | DR, CD19, CD20, CD5, CD22, CD23(−), CD10(−), CD43, moderate clonal SIg (IgM > IgD) | Cyclin D1 overexpressed | t(11; 14) |
| Follicular lymphoma | DR, CD19, CD20, CD5(−), CD22, CD23+/−, CD10, CD11c(−), CD43(−), very bright clonal SIg | CD10 negative <20% | t(14; 18) |
| Overexpression of BCL-2 | |||
| Clonal evolution | |||
| del (17p) | |||
| Marginal zone and associated lymphomas | DR, CD19, CD20, CD5(−), CD22, CD23(−), CD10(−), CD11c, CD25(−), CD103(−), moderate clonal SIg | SIgD rare | Trisomy 3 |
| Hairy cell leukemia | DR, CD19, CD20, CD5(−), CD22, CD23(−), CD10(−), CD11c, CD25, CD103, moderate clonal SIg | SIgD common, very bright CD22 and CD11c | No consistent alteration |
| Plasma cell dyscrasias | DR(−), CD19(−), CD20(−), CD22(−), CD38, CD45, clonal cIg, clonal SIg−/+ | Two color bright CD38 and dim CD45 sensitive marker | No consistent alteration |
| Disorder . | Common Phenotype . | Comments/Variations . | Potentially Associated Genetic Abnormalities . |
|---|---|---|---|
| Chronic lymphocytic leukemia/small cell lymphocytic lymphoma | DR, CD19, CD20, CD5, CD22(−), CD23, CD10(−), CD11c+/−, CD25+/−, CD43, clonal SIgM and SIgD weak | CD20 dim | Abnormalities of 13q, 14q, 11q |
| BCL-2 overexpressed | |||
| Bright SIg, CD20, FMC7 | |||
| Trisomy 12 | |||
| Prolymphocytic leukemia | DR, CD19, CD20, CD5(−), CD22, CD23(−), CD10(−), bright clonal SIg | CD20 bright | No consistent alteration |
| Mantle cell lymphoma | DR, CD19, CD20, CD5, CD22, CD23(−), CD10(−), CD43, moderate clonal SIg (IgM > IgD) | Cyclin D1 overexpressed | t(11; 14) |
| Follicular lymphoma | DR, CD19, CD20, CD5(−), CD22, CD23+/−, CD10, CD11c(−), CD43(−), very bright clonal SIg | CD10 negative <20% | t(14; 18) |
| Overexpression of BCL-2 | |||
| Clonal evolution | |||
| del (17p) | |||
| Marginal zone and associated lymphomas | DR, CD19, CD20, CD5(−), CD22, CD23(−), CD10(−), CD11c, CD25(−), CD103(−), moderate clonal SIg | SIgD rare | Trisomy 3 |
| Hairy cell leukemia | DR, CD19, CD20, CD5(−), CD22, CD23(−), CD10(−), CD11c, CD25, CD103, moderate clonal SIg | SIgD common, very bright CD22 and CD11c | No consistent alteration |
| Plasma cell dyscrasias | DR(−), CD19(−), CD20(−), CD22(−), CD38, CD45, clonal cIg, clonal SIg−/+ | Two color bright CD38 and dim CD45 sensitive marker | No consistent alteration |
Abbreviations: +/−, variable, more often positive; −/+, variable, more often negative; (−), negative; DR, HLA-DR; SIg, surface Ig; cIg, cytoplasmic Ig.