ALL
| Subtype . | Common Phenotype . | Comments/Variations . | Potentially Associated Genetic Abnormalities . |
|---|---|---|---|
| B-precursor ALL | DR, CD19, CD20−/+, CD24, CD10, CD34, TdT | t(12; 21) in 20-25% | |
| Frequently hyperdiploid | |||
| Multiple myeloid antigens | t(9; 22) | ||
| Infants with CD10(−), CD15, CD69 | 11q23 rearrangements | ||
| Pre-B ALL | DR, CD19, CD20+/−, CD24, CD9, CD10, CD34(−), cIgM, TdT+/− | CD19, CD10, CD9, CD20+/−, CD34(−) | t(1; 19) |
| B-ALL | DR, CD19, CD20, CD22, CD24, CD10+/−, CD34(−), TdT(−), SIg | Bright clonal SIg (usually IgM) | t(8; 14), t(2; 8), t(8; 22) |
| T-ALL | DR−/+, CD1, CD2, cCD3, CD5, CD7, dual CD4/CD8, CD10+/−, CD34−/+, CD45 weak, TdT | Frequently lose T-cell antigens | 15-25% have t(1; 14) |
| CD10(−) may have poor prognosis |
| Subtype . | Common Phenotype . | Comments/Variations . | Potentially Associated Genetic Abnormalities . |
|---|---|---|---|
| B-precursor ALL | DR, CD19, CD20−/+, CD24, CD10, CD34, TdT | t(12; 21) in 20-25% | |
| Frequently hyperdiploid | |||
| Multiple myeloid antigens | t(9; 22) | ||
| Infants with CD10(−), CD15, CD69 | 11q23 rearrangements | ||
| Pre-B ALL | DR, CD19, CD20+/−, CD24, CD9, CD10, CD34(−), cIgM, TdT+/− | CD19, CD10, CD9, CD20+/−, CD34(−) | t(1; 19) |
| B-ALL | DR, CD19, CD20, CD22, CD24, CD10+/−, CD34(−), TdT(−), SIg | Bright clonal SIg (usually IgM) | t(8; 14), t(2; 8), t(8; 22) |
| T-ALL | DR−/+, CD1, CD2, cCD3, CD5, CD7, dual CD4/CD8, CD10+/−, CD34−/+, CD45 weak, TdT | Frequently lose T-cell antigens | 15-25% have t(1; 14) |
| CD10(−) may have poor prognosis |
Abbreviations: +/−, variable, more often positive; −/+, variable, more often negative; (−), negative; DR, HLA-DR; SIg, surface Ig; cIg, cytoplasmic Ig; cCD3, cytoplasmic CD3.