Table 1. Correlation Between Cytogenetic... | American Society of Hematology

Table 1.

Correlation Between Cytogenetic Status of Chromosome 17, Mutation in P53, Protein Expression, and Duration of Survival in Different Histologic Types of B-NHL

Tumor No.	Histologic Type	Chromosome 17p Status^*	Codon	Codon Change	Amino Acid Change	Protein Expression^†	Survival (mo)
1095	SLL	Normal	147-153	21-bp duplication	Frame shift	+	NA
323	FSCC	Normal	215	AGT → ATT	Ser → Isol
			261	AGG → AGT	Arg → Ser	+	T/60
840	FSCC	Loss	234	TAC → AAC	Tyr → Asp	+	?D/88
907	FMx	Loss	150-154	13-bp deletion	Frame shift	−	NA
1786	FMx	Deletion	131	3-bp deletion	Frame shift	−	D/50+
459	FLC	Abnormal	241	TCC → CCC	Ser → Pro	+	NA
2303	DSCC	Not done	194	CTT → CGT	Leu → Arg	+	D/5
1272	DMx	Normal	280	AGA → ACA	Arg → Thr	+++	D/NA
1505	DMx	Normal	273	CGT → TGT	Arg → Cys	+	D/10
541	DLC	Normal	248	CGG → CAG	Arg → Gln	+	NA
591	DLC	Deleted	145	CTG → CCG	Leu → Pro	+++	NA
629	DLC	Failure	205	TAT → TGT	Tyr → Cys
			239	AAC → GAC	Asn → Asp	+++	D/24
834	DLC	Loss	282	CGG → TGG	Arg → Trp	+	NA
919	DLC	Failure	240	AGT → AGG	Ser → Arg	+++	D/4
1017	DLC	Failure	175	CGC → CAC	Arg → His	++	D/6
1049	DLC	Not done	220	TAT → TGT	Tyr → Cys	−	D/14
1765	DLC	Loss	272	GTG → GAG	Val → Glu	−	D/6
1866	DLC	Normal	213	CGA → TGA	Arg → Stop	−	D/NA
1995^‡	DLC	Deletion	132	AAG → AAC	Lys → Asp	+++	D/21
2117	DLC	Abnormal	237	ATG → ATA	Met → Isol	+	T/89+
2400^‡	DLC	Deletion	132	AAG → AAC	Lys → Asp	+++
2432	DLC	Normal	288-289	2-bp deletion	Frame shift	++	D/10
2590	DLC	Normal	248	CGG → CAG	Arg → Gln	+++	D/24
2902	DLC	Failure	220	TAT → TCT	Tyr → Ser	++	T/229+
3444	DLC	Not done	132	AAG → GAG	Lys → Glu	++	D/28
3610	DLC	Loss	196	CGA → TGA	Arg → stop	−	D/1

Tumor No.	Histologic Type	Chromosome 17p Status^*	Codon	Codon Change	Amino Acid Change	Protein Expression^†	Survival (mo)
1095	SLL	Normal	147-153	21-bp duplication	Frame shift	+	NA
323	FSCC	Normal	215	AGT → ATT	Ser → Isol
			261	AGG → AGT	Arg → Ser	+	T/60
840	FSCC	Loss	234	TAC → AAC	Tyr → Asp	+	?D/88
907	FMx	Loss	150-154	13-bp deletion	Frame shift	−	NA
1786	FMx	Deletion	131	3-bp deletion	Frame shift	−	D/50+
459	FLC	Abnormal	241	TCC → CCC	Ser → Pro	+	NA
2303	DSCC	Not done	194	CTT → CGT	Leu → Arg	+	D/5
1272	DMx	Normal	280	AGA → ACA	Arg → Thr	+++	D/NA
1505	DMx	Normal	273	CGT → TGT	Arg → Cys	+	D/10
541	DLC	Normal	248	CGG → CAG	Arg → Gln	+	NA
591	DLC	Deleted	145	CTG → CCG	Leu → Pro	+++	NA
629	DLC	Failure	205	TAT → TGT	Tyr → Cys
			239	AAC → GAC	Asn → Asp	+++	D/24
834	DLC	Loss	282	CGG → TGG	Arg → Trp	+	NA
919	DLC	Failure	240	AGT → AGG	Ser → Arg	+++	D/4
1017	DLC	Failure	175	CGC → CAC	Arg → His	++	D/6
1049	DLC	Not done	220	TAT → TGT	Tyr → Cys	−	D/14
1765	DLC	Loss	272	GTG → GAG	Val → Glu	−	D/6
1866	DLC	Normal	213	CGA → TGA	Arg → Stop	−	D/NA
1995^‡	DLC	Deletion	132	AAG → AAC	Lys → Asp	+++	D/21
2117	DLC	Abnormal	237	ATG → ATA	Met → Isol	+	T/89+
2400^‡	DLC	Deletion	132	AAG → AAC	Lys → Asp	+++
2432	DLC	Normal	288-289	2-bp deletion	Frame shift	++	D/10
2590	DLC	Normal	248	CGG → CAG	Arg → Gln	+++	D/24
2902	DLC	Failure	220	TAT → TCT	Tyr → Ser	++	T/229+
3444	DLC	Not done	132	AAG → GAG	Lys → Glu	++	D/28
3610	DLC	Loss	196	CGA → TGA	Arg → stop	−	D/1

Abbreviations: D, specimen studied at diagnosis; T, specimen studied after transformation; NA, data not available.

Loss, monosomy; deletion, deletion of short arm.

†

+, 10% to 25% cells positive; ++, 26% to 50% cells positive; +++, >51% cells positive.

‡

Specimens obtained from the same patient at different times.

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