Apoptosis Induced by Idarubicin 50 μg/L After 24 hours: Mean % Cells Apoptotic (SD)
| Cell Line/Treatment . | Control . | GM-CSF . | ATRA . | ATRA + GM-CSF . | 1,25(OH)2 D3 . | 1,25(OH)2 D3 + GM-CSF . |
|---|---|---|---|---|---|---|
| HL60 n = 3 | 30.2 (9.5) | 33.3 (12.3) | 7.0 (1.2) | 9.3 (1.6) | 10.2 (5.1) | 10.4 (4.7) |
| U937 n = 7 | 27.9 (12.0) | 21.6 (6.6) | 13.1 (4.8) | 4.2 (2.8) | 21.9 (8.2) | 9.2 (4.4) |
| KG1 n = 3 | 30.1 (4.6) | 32.0 (8.0) | 8.3 (4.7) | 15.1 (4.0) | 11.8 (6.1) | 16.7 (7.0) |
| Cell Line/Treatment . | Control . | GM-CSF . | ATRA . | ATRA + GM-CSF . | 1,25(OH)2 D3 . | 1,25(OH)2 D3 + GM-CSF . |
|---|---|---|---|---|---|---|
| HL60 n = 3 | 30.2 (9.5) | 33.3 (12.3) | 7.0 (1.2) | 9.3 (1.6) | 10.2 (5.1) | 10.4 (4.7) |
| U937 n = 7 | 27.9 (12.0) | 21.6 (6.6) | 13.1 (4.8) | 4.2 (2.8) | 21.9 (8.2) | 9.2 (4.4) |
| KG1 n = 3 | 30.1 (4.6) | 32.0 (8.0) | 8.3 (4.7) | 15.1 (4.0) | 11.8 (6.1) | 16.7 (7.0) |
ANOVA P values for ATRA, 1,25(OH)2 D3 and GM-CSF effects: ATRA-HL60 P = .02, U937 P < .001, KG1 P < .01; 1,25(OH)2 D3-HL60 P = .02, U937 P < .01, KG1 P < .01; GM-CSF-HL60 P = .02, U937 P < .001, KG1 P < .001.