Analysis of Normal and Jaundiced Serum
| Parameters . | Phenotype . | |
|---|---|---|
| . | Normal . | Jaundiced . |
| Part A | ||
| Total bilirubin (mg/dL) | 0.3 ± 0.1 (5)* | 1.9 ± 0.4 (5)† |
| Direct (mg/dL) | 0.0 ± 0.0 (5) | 0.7 ± 0.2 (5)† |
| Indirect (mg/dL) | 0.3 ± 0.1 (5) | 1.2 ± 0.2 (5)† |
| BUN (mg/dL) | 30 ± 3 (5) | 39 ± 4 (5)† |
| Glucose (mg/dL) | 206 ± 34 (5) | 151 ± 7 (5)† |
| Part B | ||
| Serum total iron ( μg/dL) | 125 ± 29 (11) | 350 ± 48 (11)‡ |
| UIBC ( μg/dL) | 184 ± 57 (6) | 96 ± 23 (6)† |
| TIBC ( μg/dL) | 312 ± 39 (6) | 448 ± 77 (6)† |
| Percent saturation (%) | 42 ± 12 (6) | 78 ± 4 (6)† |
| Parameters . | Phenotype . | |
|---|---|---|
| . | Normal . | Jaundiced . |
| Part A | ||
| Total bilirubin (mg/dL) | 0.3 ± 0.1 (5)* | 1.9 ± 0.4 (5)† |
| Direct (mg/dL) | 0.0 ± 0.0 (5) | 0.7 ± 0.2 (5)† |
| Indirect (mg/dL) | 0.3 ± 0.1 (5) | 1.2 ± 0.2 (5)† |
| BUN (mg/dL) | 30 ± 3 (5) | 39 ± 4 (5)† |
| Glucose (mg/dL) | 206 ± 34 (5) | 151 ± 7 (5)† |
| Part B | ||
| Serum total iron ( μg/dL) | 125 ± 29 (11) | 350 ± 48 (11)‡ |
| UIBC ( μg/dL) | 184 ± 57 (6) | 96 ± 23 (6)† |
| TIBC ( μg/dL) | 312 ± 39 (6) | 448 ± 77 (6)† |
| Percent saturation (%) | 42 ± 12 (6) | 78 ± 4 (6)† |
For Part A, age range of mice studied was 4 to 5.25 months old, average 4.6 months old, none moribund at time of analysis. For Part B, age range of mice studied was 2 to 5.5 months old, average 3.8 months old (serum total iron) or 3.1 months old (all other values), none moribund at time of analysis.
Abbreviations: BUN, blood urea nitrogen; UIBC, unsaturated iron binding capacity; TIBC, total iron binding capacity.
Mean ± standard deviation; number of observations in parentheses.
Very significant difference (P < .005); ‡ extremely significant difference (P < .0005) when compared to normal. Significance determined by Mann-Whitney unpaired nonparametric test.