Induction of E- and P-Selectin Protein in LPS- or TNF-α Treated Mice
| Organ . | E-Selectin . | P-Selectin . |
|---|---|---|
| Brain + spinal cord | ⊘ | ⊘ |
| Kidney | On glomerular capillaries | On large venules |
| Tongue | Many venules + some capillaries | On large venules |
| Gut | Venules + some capillaries | +/− on some venules |
| Skin | On Capillaries and some venules | +/− on some venules |
| Spleen | On arterioles in white pulp | ⊘ |
| Thymus | On venules | Trabecular venules |
| Lymph node | +/− on HEVs | +/− on HEVs |
| Organ . | E-Selectin . | P-Selectin . |
|---|---|---|
| Brain + spinal cord | ⊘ | ⊘ |
| Kidney | On glomerular capillaries | On large venules |
| Tongue | Many venules + some capillaries | On large venules |
| Gut | Venules + some capillaries | +/− on some venules |
| Skin | On Capillaries and some venules | +/− on some venules |
| Spleen | On arterioles in white pulp | ⊘ |
| Thymus | On venules | Trabecular venules |
| Lymph node | +/− on HEVs | +/− on HEVs |
In total 12 mice consisting of 4 mice each of the strains SJL/J, C57Bl/6, and Balb/C mice were investigated. From each mouse strain 4 animals were sacrificed, tissue was removed and snap frozen after the following 4 treatments: IV TNF-α (50 μg, 3 hours), IV TNF-α (50 μg, 4 hours), IV LPS (50 μg, 3 hours), and IV LPS (50 μg, 4 hours). We did not observe significant differences in the inducibility of E- and P-selectin comparing the different mouse strains, treatments, and timepoints investigated.