Table 1. Interspecies Comparison of... | American Society of Hematology

Table 1.

Interspecies Comparison of Amino Acid Sequences in the COX I Region

Bacillus subtilis

S

M

V

F

A

I

V

L

I

G

F

L

G

F

M

V

W

V

H

H

M

Escherichia coli

S

L

V

W

A

T

V

C

I

T

V

L

S

F

I

V

W

L

H

H

F

Paracoccus denitrificans

P

M

V

L

A

M

A

A

I

A

F

L

G

F

I

V

W

A

H

H

M

Thermus thermophilus

Q

M

V

W

A

Q

M

G

I

V

V

L

G

T

M

V

W

A

H

H

M

Chlamydomonas reinhardtii

G

M

I

C

A

M

G

A

I

S

L

L

G

F

I

V

W

A

H

H

M

Yeast (Saccharomyces cerevisiae)

S

M

V

Y

A

M

A

S

I

G

L

L

G

F

L

V

W

S

H

H

M

Wheat (Triticum aestivum)

G

M

V

Y

A

M

I

S

I

G

V

L

G

F

L

V

W

A

H

H

M

Drosophila melanogaster

G

M

I

Y

A

M

L

A

I

G

L

L

G

F

I

V

W

A

H

H

M

Honey bee (Apis mellifera)

S

M

I

Y

A

M

L

G

I

G

F

L

G

F

I

V

W

A

H

H

M

Worm (Strongyloides purpuratus)

G

L

V

Y

A

M

I

A

I

G

V

L

G

F

L

V

W

A

H

H

M

Worm (Lumbricus terrestris)

G

M

I

Y

A

M

L

G

I

A

V

L

G

F

I

V

W

A

H

H

M

Sea urchin (Paracentrotus lividus)

G

M

V

Y

A

M

I

A

I

G

V

L

G

F

L

V

W

A

H

H

M

Cod (Gadus morhua)

G

M

V

W

A

M

M

A

I

G

L

L

G

F

I

V

W

A

H

H

M

Carp (Cyprinus carpio)

G

M

V

W

A

M

M

A

I

G

L

L

G

F

I

V

W

A

H

H

M

Trout (Oncorhynchus mykiss)

G

M

V

W

A

M

M

A

I

G

L

L

G

F

I

V

W

A

H

H

M

Frog (Xenopus laevis)

G

M

V

W

A

M

M

S

I

G

L

L

G

F

I

V

W

A

H

H

M

Seal (Phoca vitulina)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Whale (Balaenoptera musculus)

G

M

I

W

A

M

V

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Chicken (Gallus gallus)

G

M

V

W

A

M

L

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Mouse (Mus musculus)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Opossum (Didelphis virginiana)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Rhinoceros unicornis

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Cattle (Bos taurus)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Gorilla (G gorilla)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Chimpanzee (Pan troglodytes)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Man (Homo sapiens)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Patient no. 1

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

T

Patient no. 2

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

T

Bacillus subtilis

S

M

V

F

A

I

V

L

I

G

F

L

G

F

M

V

W

V

H

H

M

Escherichia coli

S

L

V

W

A

T

V

C

I

T

V

L

S

F

I

V

W

L

H

H

F

Paracoccus denitrificans

P

M

V

L

A

M

A

A

I

A

F

L

G

F

I

V

W

A

H

H

M

Thermus thermophilus

Q

M

V

W

A

Q

M

G

I

V

V

L

G

T

M

V

W

A

H

H

M

Chlamydomonas reinhardtii

G

M

I

C

A

M

G

A

I

S

L

L

G

F

I

V

W

A

H

H

M

Yeast (Saccharomyces cerevisiae)

S

M

V

Y

A

M

A

S

I

G

L

L

G

F

L

V

W

S

H

H

M

Wheat (Triticum aestivum)

G

M

V

Y

A

M

I

S

I

G

V

L

G

F

L

V

W

A

H

H

M

Drosophila melanogaster

G

M

I

Y

A

M

L

A

I

G

L

L

G

F

I

V

W

A

H

H

M

Honey bee (Apis mellifera)

S

M

I

Y

A

M

L

G

I

G

F

L

G

F

I

V

W

A

H

H

M

Worm (Strongyloides purpuratus)

G

L

V

Y

A

M

I

A

I

G

V

L

G

F

L

V

W

A

H

H

M

Worm (Lumbricus terrestris)

G

M

I

Y

A

M

L

G

I

A

V

L

G

F

I

V

W

A

H

H

M

Sea urchin (Paracentrotus lividus)

G

M

V

Y

A

M

I

A

I

G

V

L

G

F

L

V

W

A

H

H

M

Cod (Gadus morhua)

G

M

V

W

A

M

M

A

I

G

L

L

G

F

I

V

W

A

H

H

M

Carp (Cyprinus carpio)

G

M

V

W

A

M

M

A

I

G

L

L

G

F

I

V

W

A

H

H

M

Trout (Oncorhynchus mykiss)

G

M

V

W

A

M

M

A

I

G

L

L

G

F

I

V

W

A

H

H

M

Frog (Xenopus laevis)

G

M

V

W

A

M

M

S

I

G

L

L

G

F

I

V

W

A

H

H

M

Seal (Phoca vitulina)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Whale (Balaenoptera musculus)

G

M

I

W

A

M

V

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Chicken (Gallus gallus)

G

M

V

W

A

M

L

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Mouse (Mus musculus)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Opossum (Didelphis virginiana)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Rhinoceros unicornis

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Cattle (Bos taurus)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Gorilla (G gorilla)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Chimpanzee (Pan troglodytes)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Man (Homo sapiens)

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

Patient no. 1

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

T

Patient no. 2

G

M

V

W

A

M

M

S

I

G

F

L

G

F

I

V

W

A

H

H

M

T

The amino acids mutated in patients no. 1 and 2, Met²⁷³ and Ile²⁸⁰ according to the human sequence, have been strongly conserved during evolution. Sequence data are from earlier studies.29 72-93