Table 5.

Complete Remission Rate by Disease Status, Cytogenetic Status, and MDR1 Expression

MDR1 ExpressionSecondary AML
UnfavorableIntermed/FavorableDe Novo AML
PtsCRs%CRPtsCRs%CRUnfavorableIntermed/Favorable
PtsCRs%CRPtsCRs%CR
Bright/moderate positive (≥0.15) 15 13 11 17 24 40 19 48 
Dim positive (0.10-0.14) 33 50 16 10 63 
Negative (<0.10) 57 27 22 81 
MDR1 ExpressionSecondary AML
UnfavorableIntermed/FavorableDe Novo AML
PtsCRs%CRPtsCRs%CRUnfavorableIntermed/Favorable
PtsCRs%CRPtsCRs%CR
Bright/moderate positive (≥0.15) 15 13 11 17 24 40 19 48 
Dim positive (0.10-0.14) 33 50 16 10 63 
Negative (<0.10) 57 27 22 81 

Results for 146 patients with complete clinical and biologic data.

Abbreviation: Pts, patients.

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