Treatment Outcomes by AML Onset, CD34, MDR1, Cytogenetic Status, and Efflux in 211 Elderly AML Patients
. | Patients . | Response to Treatment . | |||
---|---|---|---|---|---|
. | No. . | % . | CRs . | % CR . | Univariate P Value . |
AML onset | |||||
Secondary | 50 | 24 | 12 | 24 | .0005 |
De novo | 161 | 76 | 83 | 52 | |
CD34 expression | |||||
Positive | 138 | 68 | 53 | 38 | .0027 |
Negative | 66 | 32 | 39 | 59 | |
MRK16 expression | |||||
Bright/moderate (+) | 102 | 54 | 35 | 34 | .0019 |
Dim (+) | 33 | 17 | 15 | 45 | |
Negative | 54 | 29 | 36 | 67 | |
Cytogenetic status | |||||
Unfavorable | 52 | 32 | 11 | 21 | <.0001 |
Intermediate/favorable | 112 | 68 | 62 | 55 | |
Functional efflux | |||||
Positive | 101 | 58 | 35 | 35 | .0039 |
Negative | 74 | 42 | 43 | 58 |
. | Patients . | Response to Treatment . | |||
---|---|---|---|---|---|
. | No. . | % . | CRs . | % CR . | Univariate P Value . |
AML onset | |||||
Secondary | 50 | 24 | 12 | 24 | .0005 |
De novo | 161 | 76 | 83 | 52 | |
CD34 expression | |||||
Positive | 138 | 68 | 53 | 38 | .0027 |
Negative | 66 | 32 | 39 | 59 | |
MRK16 expression | |||||
Bright/moderate (+) | 102 | 54 | 35 | 34 | .0019 |
Dim (+) | 33 | 17 | 15 | 45 | |
Negative | 54 | 29 | 36 | 67 | |
Cytogenetic status | |||||
Unfavorable | 52 | 32 | 11 | 21 | <.0001 |
Intermediate/favorable | 112 | 68 | 62 | 55 | |
Functional efflux | |||||
Positive | 101 | 58 | 35 | 35 | .0039 |
Negative | 74 | 42 | 43 | 58 |