Table 2.

Subsequent Cancers in Patients Potentially Cured of AML

Patient No.Subsequent CancerAge at Diagnosis Subsequent CancerSexYears From Entry Into Potentially Cured Cohort to First Diagnosis of Subsequent Cancer*Cytogenetics at Leukemia DiagnosisLeukemia Treatment Initial/Salvage
Colon-adenocarcinoma 68 Normal ROAP 
Colon-adenocarcinoma 77 Complex-7 ADOAP/ADOAP 
Lung-carcinoid/colon/breast 69 14 Normal (unbanded) ADOAP 
Lung-small cell carcinoma 62 18 Insufficient ADOAP 
Lung-adenocarcinoma 65 Normal (unbanded) ROAP 
Pancreas/melanoma 68 Normal AMSA + OAP 
Prostate 60 Inv 16 IDA + HDAC 
Prostate 73 t(8; 21) AMSA + OAP 
Breast 51 Inv 16 AMSA + OAP 
10 Endometrial 82 17 Insufficient ADOAP 
11 Endometrial 58 11 t(8; 21) (unbanded) ADOAP/ADOAP 
12 Penile-squamous 49 14 47XY + G (unbanded) ARA-C 
13 Lymphoma-NHL 48 13 Normal ADOAP 
14 Lymphoma-DLCL 63 Inversion 5, +8, +4 HDAC/FLUDARABINE + ARA-C 
15 Bladder-TCC 58 +8 (unbanded) ADOAP 
Patient No.Subsequent CancerAge at Diagnosis Subsequent CancerSexYears From Entry Into Potentially Cured Cohort to First Diagnosis of Subsequent Cancer*Cytogenetics at Leukemia DiagnosisLeukemia Treatment Initial/Salvage
Colon-adenocarcinoma 68 Normal ROAP 
Colon-adenocarcinoma 77 Complex-7 ADOAP/ADOAP 
Lung-carcinoid/colon/breast 69 14 Normal (unbanded) ADOAP 
Lung-small cell carcinoma 62 18 Insufficient ADOAP 
Lung-adenocarcinoma 65 Normal (unbanded) ROAP 
Pancreas/melanoma 68 Normal AMSA + OAP 
Prostate 60 Inv 16 IDA + HDAC 
Prostate 73 t(8; 21) AMSA + OAP 
Breast 51 Inv 16 AMSA + OAP 
10 Endometrial 82 17 Insufficient ADOAP 
11 Endometrial 58 11 t(8; 21) (unbanded) ADOAP/ADOAP 
12 Penile-squamous 49 14 47XY + G (unbanded) ARA-C 
13 Lymphoma-NHL 48 13 Normal ADOAP 
14 Lymphoma-DLCL 63 Inversion 5, +8, +4 HDAC/FLUDARABINE + ARA-C 
15 Bladder-TCC 58 +8 (unbanded) ADOAP 

Abbreviations: NHL, non-Hodgkin's lymphoma; DLCL, diffuse large-cell lymphoma; TCC, transitional cell carcinoma; ADOAP, adriomycin, ara-C, vincristine, prednisone; ROAP, rubidazone, ara-C, vincristine, prednisone; HDAC, high-dose ara-C.

*

Add 3 years to determine time from initial AML therapy to subsequent cancer.

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