Primary Tumor Development in Control and Plg−/− Mice
| Experiment No. . | Mice Developing Tumors . | 1st Tumor (day)* (mean ± SD) . | Tumor Size (g)† (mean ± SD) . | |||||
|---|---|---|---|---|---|---|---|---|
| . | Control . | Plg−/− . | Control . | Plg−/− . | Day . | Control . | Plg−/− . | P Value‡ . |
| 1 | 13/13 | 17/17 | 1.9 ± 0.9 | 2.4 ± 0.9 NS | 2 | 0.03 ± 0.03 (13) | 0.03 ± 0.05 (17) | NS |
| 4 | 0.07 ± 0.04 (13) | 0.04 ± 0.02 (17) | <.04 | |||||
| 6 | 0.22 ± 0.07 (13) | 0.13 ± 0.07 (17) | <.004 | |||||
| 7 | 0.26 ± 0.09ρ (4) | 0.18 ± 0.08ρ (10) | <.05 | |||||
| 8 | 0.48 ± 0.18 (9) | 0.25 ± 0.13 (7) | <.02 | |||||
| 10 | 0.83 ± 0.30 (9) | 0.44 ± 0.14 (7) | <.008 | |||||
| 12 | 1.2 ± 0.5 (9) | 0.76 ± 0.25 (7) | <.05 | |||||
| 14 | 2.1 ± 0.8 (9) | 1.3 ± 0.5 (7) | <.04 | |||||
| 16 | 3.1 ± 0.8 (9) | 1.9 ± 0.8 (7) | <.02 | |||||
| 18 | 3.6 ± 1.2 (9) | 2.2 ± 0.6 (7) | <.03 | |||||
| 2 | 14/14 | 14/14 | 2.2 ± 0.6 | 2.5 ± 0.7 NS | 2 | 0.02 ± 0.02 (13) | 0.01 ± 0.01 (13) | NS |
| 4 | 0.06 ± 0.01 (13) | 0.03 ± 0.01 (13) | <.0001 | |||||
| 6 | 0.26 ± 0.05 (13) | 0.17 ± 0.07 (13) | <.001 | |||||
| 8 | 0.42 ± 0.10 (13) | 0.28 ± 0.10 (12) | <.001 | |||||
| 10 | 0.86 ± 0.24 (14) | 0.58 ± 0.21 (13) | <.005 | |||||
| 12 | 1.4 ± 0.5 (14) | 1.0 ± 0.4 (13) | <.05 | |||||
| 14 | 2.2 ± 0.8 (14) | 1.7 ± 0.7 (13) | NS | |||||
| 16 | 3.1 ± 1.1 (14) | 2.8 ± 1.0 (13) | NS | |||||
| 3 | 12/12 | 12/12 | 2.3 ± 0.5 | 2.6 ± 1.2 NS | 2 | 0.01 ± 0.01 (8) | 0.00 ± 0.01 (8) | NS |
| 4 | 0.05 ± 0.02 (9) | 0.03 ± 0.01 (8) | <.02 | |||||
| 6 | 0.23 ± 0.06ρ (3) | 0.10 ± 0.02ρ (3) | <.03 | |||||
| 4 | 15/15 | 15/15 | ND | ND | 6 | 0.18 ± 0.05 (4) | 0.09 ± 0.05 (4) | <.04 |
| Experiment No. . | Mice Developing Tumors . | 1st Tumor (day)* (mean ± SD) . | Tumor Size (g)† (mean ± SD) . | |||||
|---|---|---|---|---|---|---|---|---|
| . | Control . | Plg−/− . | Control . | Plg−/− . | Day . | Control . | Plg−/− . | P Value‡ . |
| 1 | 13/13 | 17/17 | 1.9 ± 0.9 | 2.4 ± 0.9 NS | 2 | 0.03 ± 0.03 (13) | 0.03 ± 0.05 (17) | NS |
| 4 | 0.07 ± 0.04 (13) | 0.04 ± 0.02 (17) | <.04 | |||||
| 6 | 0.22 ± 0.07 (13) | 0.13 ± 0.07 (17) | <.004 | |||||
| 7 | 0.26 ± 0.09ρ (4) | 0.18 ± 0.08ρ (10) | <.05 | |||||
| 8 | 0.48 ± 0.18 (9) | 0.25 ± 0.13 (7) | <.02 | |||||
| 10 | 0.83 ± 0.30 (9) | 0.44 ± 0.14 (7) | <.008 | |||||
| 12 | 1.2 ± 0.5 (9) | 0.76 ± 0.25 (7) | <.05 | |||||
| 14 | 2.1 ± 0.8 (9) | 1.3 ± 0.5 (7) | <.04 | |||||
| 16 | 3.1 ± 0.8 (9) | 1.9 ± 0.8 (7) | <.02 | |||||
| 18 | 3.6 ± 1.2 (9) | 2.2 ± 0.6 (7) | <.03 | |||||
| 2 | 14/14 | 14/14 | 2.2 ± 0.6 | 2.5 ± 0.7 NS | 2 | 0.02 ± 0.02 (13) | 0.01 ± 0.01 (13) | NS |
| 4 | 0.06 ± 0.01 (13) | 0.03 ± 0.01 (13) | <.0001 | |||||
| 6 | 0.26 ± 0.05 (13) | 0.17 ± 0.07 (13) | <.001 | |||||
| 8 | 0.42 ± 0.10 (13) | 0.28 ± 0.10 (12) | <.001 | |||||
| 10 | 0.86 ± 0.24 (14) | 0.58 ± 0.21 (13) | <.005 | |||||
| 12 | 1.4 ± 0.5 (14) | 1.0 ± 0.4 (13) | <.05 | |||||
| 14 | 2.2 ± 0.8 (14) | 1.7 ± 0.7 (13) | NS | |||||
| 16 | 3.1 ± 1.1 (14) | 2.8 ± 1.0 (13) | NS | |||||
| 3 | 12/12 | 12/12 | 2.3 ± 0.5 | 2.6 ± 1.2 NS | 2 | 0.01 ± 0.01 (8) | 0.00 ± 0.01 (8) | NS |
| 4 | 0.05 ± 0.02 (9) | 0.03 ± 0.01 (8) | <.02 | |||||
| 6 | 0.23 ± 0.06ρ (3) | 0.10 ± 0.02ρ (3) | <.03 | |||||
| 4 | 15/15 | 15/15 | ND | ND | 6 | 0.18 ± 0.05 (4) | 0.09 ± 0.05 (4) | <.04 |
Abbreviations: ND, not done; SD, standard deviation; NS, not significant (P > .05).
Determined by visual inspection of mice.
Tumor size was determined by calipation as described in Material and Methods or by direct measurement as indicated. Numbers in parentheses indicate the number of mice included in measurements.
P values were determined by the Student's t-test (two-tailed).
ρ Direct determination of the weight of excised tumors.