Distribution of CD138/Syndecan-1 Expression as Assessed by the B-B4 MoAb Reactivity Among Lymphomatous Effusions, Tissue-Based Lymphomas, and Plasmacytoma/Myeloma
| Diagnosis . | Positive/Tested . |
|---|---|
| Primary lymphomatous effusions | |
| DLCL | 0/2 |
| SNCCL (Burkitt's lymphoma) | 0/1 |
| PEL | 10/12* |
| Secondary lymphomatous effusions | |
| DLCL | 0/8 |
| SNCCL (Burkitt's lymphoma) | 0/2 |
| Tissue-based lymphomas | |
| SLL | 0/58 |
| LPL | 3/4 |
| MCL | 0/7 |
| FCCL | 0/10 |
| DLCL | 2/18† |
| SNCCL (Burkitt's lymphoma) | 0/6 |
| Plasmacytoma/myeloma | 41/41 |
| Diagnosis . | Positive/Tested . |
|---|---|
| Primary lymphomatous effusions | |
| DLCL | 0/2 |
| SNCCL (Burkitt's lymphoma) | 0/1 |
| PEL | 10/12* |
| Secondary lymphomatous effusions | |
| DLCL | 0/8 |
| SNCCL (Burkitt's lymphoma) | 0/2 |
| Tissue-based lymphomas | |
| SLL | 0/58 |
| LPL | 3/4 |
| MCL | 0/7 |
| FCCL | 0/10 |
| DLCL | 2/18† |
| SNCCL (Burkitt's lymphoma) | 0/6 |
| Plasmacytoma/myeloma | 41/41 |
Reactivity with the anti-CD138/syndecan-1 MoAb B-B4 was assessed by flow cytometry (FC) and frozen sections immunohisto-cytochemistry (IHC). Cells from 22 B-cell tissue-based lymphoma cases encompassing the different histotypes (10 small lymphocytic lymphoma, 3 mantle cell lymphoma, 6 follicular center cell lymphoma, and 3 diffuse large B-cell lymphoma) were analyzed by both FC and IHC.
Abbreviations: DLCL, diffuse large-cell lymphoma; SNCCL, small noncleaved cell lymphoma; PEL, primary effusion lymphoma; SLL, small lymphocytic lymphoma; LPL, lymphoplasmacytoid lymphoma; MCL, mantle cell lymphoma; FCCL, follicular center cell lymphoma.
Positive cases included 5 of 7 pathologic samples and 5 of 5 cell lines.
The 2 DLCL cases staining positive for CD138/syndecan-1 expression displayed immunoblastic plasmacytoid features.