Table 4. Pharmacokinetic Parameters... | American Society of Hematology

Table 4.

Pharmacokinetic Parameters After Intravenous Drip of As₂O₃ in Relapsed APL Patients

Patient No.	Cpmax (μmol/L)	t1/2α	t1/2β	Vc (L)	CL(s) (L/h)	AUC (μmol/h/L)
		(h)	(h)
6	6.01	0.55	6.38	3.83	1.38	36.20
6^4-150	6.28	1.05	13.61	4.33	1.29	38.70
8	8.18	1.01	16.66	2.93	1.34	43.95
8^4-151	6.22	0.87	11.26	3.82	1.40	35.70
9	7.70	0.49	12.36	3.44	1.27	39.55
9^4-150	6.08	0.82	8.02	3.81	1.70	29.40
10	6.62	1.15	11.65	4.10	1.53	32.60
10^4-150	6.22	1.00	10.03	4.31	1.49	34.30
11	6.82	0.62	10.46	3.98	1.43	34.85
12	5.54	0.93	11.17	4.30	1.81	27.60
13	6.62	1.16	16.52	4.15	1.33	37.55
13^4-151	6.89	1.42	9.56	4.94	1.44	34.75
15	7.30	1.21	11.86	3.89	1.33	37.70

Patient No.	Cpmax (μmol/L)	t1/2α	t1/2β	Vc (L)	CL(s) (L/h)	AUC (μmol/h/L)
		(h)	(h)
6	6.01	0.55	6.38	3.83	1.38	36.20
6^4-150	6.28	1.05	13.61	4.33	1.29	38.70
8	8.18	1.01	16.66	2.93	1.34	43.95
8^4-151	6.22	0.87	11.26	3.82	1.40	35.70
9	7.70	0.49	12.36	3.44	1.27	39.55
9^4-150	6.08	0.82	8.02	3.81	1.70	29.40
10	6.62	1.15	11.65	4.10	1.53	32.60
10^4-150	6.22	1.00	10.03	4.31	1.49	34.30
11	6.82	0.62	10.46	3.98	1.43	34.85
12	5.54	0.93	11.17	4.30	1.81	27.60
13	6.62	1.16	16.52	4.15	1.33	37.55
13^4-151	6.89	1.42	9.56	4.94	1.44	34.75
15	7.30	1.21	11.86	3.89	1.33	37.70

On day 30 of remission induction.

On day 1 of consolidation treatment.