Table 3.

Main Side Effects With As2O3 Treatment

Side EffectsFrequency (%)
Skin dryness, itching, or erythematous changes 26.7 (4/15) 
Headache 6.7 (1/15) 
EKG change 
(1) low-flat T-wave 6.7 (1/15) 
(2) sinal tachycardia and I0 A-V inductive block 6.7 (1/15) 
Nausea, vomiting, or loss of appetite accompanied with lassitude 26.7 (4/15) 
Liver function* 
GPT increased 6.7 (1/15) 
GOT increased 13.3 (2/15) 
AKP increased 13.3 (2/15) 
γ-GTP increased 6.7 (1/15) 
Total bilirubin increased 6.7 (1/15) 
Enlargement of salivary gland 6.7 (1/15) 
Thyrophyma without thyroidism†‡ 6.7 (1/15) 
Arthralgia or musculogia 13.3 (2/15) 
Teeth ache 13.3 (2/15) 
Oral ulcer 6.7 (1/15) 
Hemorrhage of teeth, nose, or skin 13.3 (2/15) 
Side EffectsFrequency (%)
Skin dryness, itching, or erythematous changes 26.7 (4/15) 
Headache 6.7 (1/15) 
EKG change 
(1) low-flat T-wave 6.7 (1/15) 
(2) sinal tachycardia and I0 A-V inductive block 6.7 (1/15) 
Nausea, vomiting, or loss of appetite accompanied with lassitude 26.7 (4/15) 
Liver function* 
GPT increased 6.7 (1/15) 
GOT increased 13.3 (2/15) 
AKP increased 13.3 (2/15) 
γ-GTP increased 6.7 (1/15) 
Total bilirubin increased 6.7 (1/15) 
Enlargement of salivary gland 6.7 (1/15) 
Thyrophyma without thyroidism†‡ 6.7 (1/15) 
Arthralgia or musculogia 13.3 (2/15) 
Teeth ache 13.3 (2/15) 
Oral ulcer 6.7 (1/15) 
Hemorrhage of teeth, nose, or skin 13.3 (2/15) 

These signs were observed in *the same two patients, †the same patient, and ‡during consolidation.

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